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One-carbon metaboli...
One-carbon metabolism biomarkers and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition
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- Vrieling, Alina (författare)
- Radboud University Nijmegen
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- Bueno-De-Mesquita, H. Bas (författare)
- University of Malaya,University Medical Center Utrecht,National Institute for Public Health and the Environment (RIVM),Imperial College London
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- Ros, Martine M. (författare)
- Radboud University Nijmegen,National Institute for Public Health and the Environment (RIVM)
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- Kampman, Ellen (författare)
- Wageningen University,Radboud University Nijmegen
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- Aben, Katja K. (författare)
- Netherlands Comprehensive Cancer Organisation (IKNL),Radboud University Nijmegen
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- Buchner, Frederike L. (författare)
- National Institute for Public Health and the Environment (RIVM)
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- Jansen, Eugene H. (författare)
- National Institute for Public Health and the Environment (RIVM)
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- Roswall, Nina (författare)
- Danish Cancer Society
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- Tjonneland, Anne (författare)
- Danish Cancer Society
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- Boutron-Ruault, Marie-Christine (författare)
- University of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP),Institut Gustave Roussy
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- Cadeau, Claire (författare)
- Institut Gustave Roussy,Centre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay
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- Chang-Claude, Jenny (författare)
- University Medical Center Hamburg-Eppendorf,German Cancer Research Centre
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- Kaaks, Rudolf (författare)
- German Cancer Research Centre
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- Weikert, Steffen (författare)
- German Institute of Human Nutrition,Vivantes Humboldt Hospital
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- Boeing, Heiner (författare)
- German Institute of Human Nutrition
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- Trichopoulou, Antonia (författare)
- Hellenic Health Foundation, Athens,National and Kapodistrian University of Athens
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- Lagiou, Pagona (författare)
- National and Kapodistrian University of Athens,Harvard University,Academy of Athens
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- Trichopoulos, Dimitrios (författare)
- Hellenic Health Foundation, Athens,Harvard University,Academy of Athens
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- Sieri, Sabina (författare)
- Istituto Nazionale dei Tumori
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- Palli, Domenico (författare)
- Cancer Research and Prevention Institute (ISPO)
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- Panico, Salvatore (författare)
- University of Naples Federico II
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- Peeters, Petra H. (författare)
- Imperial College London,University Medical Center Utrecht
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- Weiderpass, Elisabete (författare)
- Karolinska Institute,Karolinska Institutet,Folkhälsan Research Center,Cancer Registry of Norway, Institute of Population-Based Cancer Research,UiT The Arctic University of Norway, Tromsø,University of Helsinki
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- Skeie, Guri (författare)
- UiT The Arctic University of Norway, Tromsø
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- Jakszyn, Paula (författare)
- Catalan Institute of Oncology
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- Chirlaque, Maria-Dolores (författare)
- CIBER Epidemiology and Public Health (CIBERESP),University of Murcia
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- Ardanaz, Eva (författare)
- CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)
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- Sanchez, Maria-Jose (författare)
- University of Granada,CIBER Epidemiology and Public Health (CIBERESP)
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- Ehrnström, Roy (författare)
- Skåne University Hospital
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- Malm, Johan (författare)
- Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups
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- Ljungberg, Börje, Professor, 1949- (författare)
- Umeå University,Umeå universitet,Urologi och andrologi
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- Khaw, Kay-Tee (författare)
- University of Cambridge
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- Wareham, Nick J. (författare)
- University of Cambridge
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- Brennan, Paul (författare)
- International Agency for Research on Cancer, World Health Organization
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- Johansson, Mattias (författare)
- Umeå University,Umeå universitet,Enheten för biobanksforskning,Genetic Epidemiology Group, International Agency for Research on Cancer (IARC), Lyon, France,International Agency for Research on Cancer, World Health Organization
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- Riboli, Elio (författare)
- Imperial College London
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- Kiemeney, Lambertus A. (författare)
- Radboud University Medical Center
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(creator_code:org_t)
- John Wiley & Sons, 2019
- 2019
- Engelska.
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Ingår i: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 145:9, s. 2349-2359
- Relaterad länk:
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https://onlinelibrar...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Published associations between dietary folate and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status. This nested case-control analysis within the European Prospective Investigation into Cancer and Nutrition (EPIC) investigated associations between pre-diagnostic serum folate, homocysteine, vitamins B6 and B12 and the risk of urothelial cell carcinomas of the bladder (UCC). A total of 824 patients with newly diagnosed UCC were matched with 824 cohort members. Serum folate, homocysteine, and vitamins B6 and B12 were measured. Odds ratios (OR) and 95% confidence intervals (CI) for total, aggressive, and non-aggressive UCC were estimated using conditional logistic regression with adjustment for smoking status, smoking duration and intensity, and other potential confounders. Additionally, statistical interaction with smoking status was assessed. A halving in serum folate concentrations was moderately associated with risk of UCC (OR: 1.18; 95% CI: 0.98-1.43), in particular aggressive UCC (OR: 1.34; 95% CI: 1.02-1.75; p-heterogeneity = 0.19). Compared to never smokers in the highest quartile of folate concentrations, this association seemed only apparent among current smokers in the lowest quartile of folate concentrations (OR: 6.26; 95% CI: 3.62-10.81, p-interaction = 0.07). Dietary folate was not associated with aggressive UCC (OR: 1.26; 95% CI: 0.81-1.95; p-heterogeneity = 0.14). No association was observed between serum homocysteine, vitamins B6 and B12 and risk of UCC. This study suggests that lower serum folate concentrations are associated with increased UCC risk, in particular aggressive UCC. Residual confounding by smoking cannot be ruled out and these findings require confirmation in future studies with multiple measurements.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- urothelial cell carcinomas
- folate
- B-vitamins
- biomarker
- nested case-control
- B-vitamins
- biomarker
- folate
- nested case–control
- urothelial cell carcinomas
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Vrieling, Alina
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Bueno-De-Mesquit ...
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Ros, Martine M.
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Kampman, Ellen
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Aben, Katja K.
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Buchner, Frederi ...
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visa fler...
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Jansen, Eugene H ...
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Roswall, Nina
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Tjonneland, Anne
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Boutron-Ruault, ...
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Cadeau, Claire
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Chang-Claude, Je ...
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Kaaks, Rudolf
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Weikert, Steffen
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Boeing, Heiner
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Trichopoulou, An ...
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Lagiou, Pagona
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Trichopoulos, Di ...
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Sieri, Sabina
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Palli, Domenico
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Panico, Salvator ...
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Peeters, Petra H ...
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Weiderpass, Elis ...
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Skeie, Guri
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Jakszyn, Paula
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Chirlaque, Maria ...
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Ardanaz, Eva
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Sanchez, Maria-J ...
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Ehrnström, Roy
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Malm, Johan
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Ljungberg, Börje ...
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Khaw, Kay-Tee
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Wareham, Nick J.
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Brennan, Paul
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Johansson, Matti ...
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Riboli, Elio
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Kiemeney, Lamber ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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International Jo ...
- Av lärosätet
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Umeå universitet
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Karolinska Institutet
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Lunds universitet