One-carbon metabolism biomarkers and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition

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One-carbon metabolism biomarkers and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition

Vrieling, Alina (författare): Radboud University Nijmegen

Bueno-De-Mesquita, H. Bas (författare): University Medical Center Utrecht,University of Malaya,National Institute for Public Health and the Environment (RIVM),Imperial College London

Ros, Martine M. (författare): Radboud University Nijmegen,National Institute for Public Health and the Environment (RIVM)

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Kampman, Ellen (författare): Radboud University Nijmegen,Wageningen University

Aben, Katja K. (författare): Radboud University Nijmegen,Netherlands Comprehensive Cancer Organisation (IKNL)

Buchner, Frederike L. (författare): National Institute for Public Health and the Environment (RIVM)

Jansen, Eugene H. (författare): National Institute for Public Health and the Environment (RIVM)

Roswall, Nina (författare): Danish Cancer Society

Tjonneland, Anne (författare): Danish Cancer Society

Boutron-Ruault, Marie-Christine (författare): Centre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay,Institut Gustave Roussy

Cadeau, Claire (författare): Institut Gustave Roussy,Centre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay

Chang-Claude, Jenny (författare): University Medical Center Hamburg-Eppendorf,German Cancer Research Centre

Kaaks, Rudolf (författare): German Cancer Research Centre

Weikert, Steffen (författare): Vivantes Humboldt Hospital,German Institute of Human Nutrition

Boeing, Heiner (författare): German Institute of Human Nutrition

Trichopoulou, Antonia (författare): Hellenic Health Foundation, Athens,National and Kapodistrian University of Athens

Lagiou, Pagona (författare): Academy of Athens,Harvard University,National and Kapodistrian University of Athens

Trichopoulos, Dimitrios (författare): Academy of Athens,Harvard University,Hellenic Health Foundation, Athens

Sieri, Sabina (författare): Istituto Nazionale dei Tumori

Palli, Domenico (författare): Cancer Research and Prevention Institute (ISPO)

Panico, Salvatore (författare): University of Naples Federico II

Peeters, Petra H. (författare): University Medical Center Utrecht,Imperial College London

Weiderpass, Elisabete (författare): Karolinska Institutet,Cancer Registry of Norway, Institute of Population-Based Cancer Research,Folkhälsan Research Center,UiT The Arctic University of Norway, Tromsø,University of Helsinki

Skeie, Guri (författare): UiT The Arctic University of Norway, Tromsø

Jakszyn, Paula (författare): Catalan Institute of Oncology

Chirlaque, Maria-Dolores (författare): CIBER Epidemiology and Public Health (CIBERESP),University of Murcia

Ardanaz, Eva (författare): Health Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP)

Sanchez, Maria-Jose (författare): CIBER Epidemiology and Public Health (CIBERESP),University of Granada

Ehrnström, Roy (författare): Skåne University Hospital

Malm, Johan (författare): Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups

Ljungberg, Börje, Professor, 1949- (författare): Umeå University,Umeå universitet,Urologi och andrologi

Khaw, Kay-Tee (författare): University of Cambridge

Wareham, Nick J. (författare): University of Cambridge

Brennan, Paul (författare): International Agency for Research on Cancer, World Health Organization

Johansson, Mattias (författare): Umeå University,Umeå universitet,Enheten för biobanksforskning,Genetic Epidemiology Group, International Agency for Research on Cancer (IARC), Lyon, France,International Agency for Research on Cancer, World Health Organization

Riboli, Elio (författare): Imperial College London

Kiemeney, Lambertus A. (författare): Radboud University Medical Center

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John Wiley & Sons, 2019
2019
Engelska.
Ingår i: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 145:9, s. 2349-2359

Relaterad länk:: https://onlinelibrar...; visa fler...; http://dx.doi.org/10... (free); https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; https://lup.lub.lu.s...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Published associations between dietary folate and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status. This nested case-control analysis within the European Prospective Investigation into Cancer and Nutrition (EPIC) investigated associations between pre-diagnostic serum folate, homocysteine, vitamins B6 and B12 and the risk of urothelial cell carcinomas of the bladder (UCC). A total of 824 patients with newly diagnosed UCC were matched with 824 cohort members. Serum folate, homocysteine, and vitamins B6 and B12 were measured. Odds ratios (OR) and 95% confidence intervals (CI) for total, aggressive, and non-aggressive UCC were estimated using conditional logistic regression with adjustment for smoking status, smoking duration and intensity, and other potential confounders. Additionally, statistical interaction with smoking status was assessed. A halving in serum folate concentrations was moderately associated with risk of UCC (OR: 1.18; 95% CI: 0.98-1.43), in particular aggressive UCC (OR: 1.34; 95% CI: 1.02-1.75; p-heterogeneity = 0.19). Compared to never smokers in the highest quartile of folate concentrations, this association seemed only apparent among current smokers in the lowest quartile of folate concentrations (OR: 6.26; 95% CI: 3.62-10.81, p-interaction = 0.07). Dietary folate was not associated with aggressive UCC (OR: 1.26; 95% CI: 0.81-1.95; p-heterogeneity = 0.14). No association was observed between serum homocysteine, vitamins B6 and B12 and risk of UCC. This study suggests that lower serum folate concentrations are associated with increased UCC risk, in particular aggressive UCC. Residual confounding by smoking cannot be ruled out and these findings require confirmation in future studies with multiple measurements.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

urothelial cell carcinomas
folate
B-vitamins
biomarker
nested case-control
B-vitamins
biomarker
folate
nested case–control
urothelial cell carcinomas

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