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Dynamic evaluation ...
Dynamic evaluation of the immune infiltrate and immune function genes as predictive markers for neoadjuvant chemotherapy in hormone receptor positive, HER2 negative breast cancer
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- Matikas, Alexios (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Lövrot, John (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Ramberg, Anna (författare)
- Department of Clinical Pathology and Cytology, Central Hospital Karlstad, Karlstad, Sweden
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- Eriksson, Margareta (författare)
- Karolinska Institutet,Karlstad Hospital
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- Lindsten, Therese (författare)
- Department of Clinical Pathology and Cytology, Central Hospital Karlstad, Karlstad, Sweden
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- Lekberg, Tobias (författare)
- Department of Oncology, Karolinska Institutet and University Hospital, Stockholm, Sweden
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- Hedenfalk, Ingrid (författare)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Loman, Niklas (författare)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Bröstcancer-genetik,Institutionen för kliniska vetenskaper, Lund,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Breastcancer-genetics,Department of Clinical Sciences, Lund
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- Bergh, Jonas (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Hatschek, Thomas (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Erlandsson, Ann, 1968- (författare)
- Örebro University,Karlstad University,Karlstads universitet,Region Örebro län,Örebro universitet, Institutionen för medicinska vetenskaper,Department of Urology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Department of Biology, Karlstad university, Karlstad, Sweden,Institutionen för hälsovetenskaper (from 2013)
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- Foukakis, Theodoros (författare)
- Karolinska Institutet,Karolinska University Hospital
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(creator_code:org_t)
- Taylor & Francis, 2018
- 2018
- Engelska.
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Ingår i: Oncoimmunology. - : Taylor & Francis. - 2162-4011 .- 2162-402X. ; 7:9
- Relaterad länk:
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https://doi.org/10.1...
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https://kau.diva-por... (primary) (Raw object)
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Gene expression (GE) signatures and Tumor Infiltrating Lymphocytes (TIL) enumeration are predictive for response to neoadjuvant chemotherapy in HR- and in HER2+ breast cancer, but data are conflicting in HR+/HER2- disease. This study aimed to explore their predictive value in this subset, measured both at baseline and after short exposure to chemotherapy. Specifically, the PROMIX phase 2 trial enrolled patients with locally advanced HER2- BC to receive six cycles of epirubicin and docetaxel, plus bevacizumab during cycles 3-6. Patients underwent tumor biopsies at baseline and after cycle 2 for GE profiling and enumeration of TIL, FOXP3+ T-cells and CD163+ macrophages. An immune related gene module and the quantification of the immune infiltrate were analyzed for association with pathologic complete response (pCR), decrease in tumor size and disease-free survival (DFS). Of the 150 patients enrolled in PROMIX, 113 were HR+/HER2-. Baseline GE and immune cell enumeration data were available from 71 patients, while data after 2 cycles of chemotherapy were available from 41. At baseline, only GE was statistically significantly associated with higher pCR rates (OR 2.29, 95% CI 1.05 - 5.38, p = 0.037) and decrease in tumor size (r = 0.25, p = 0.047). In contrast, longitudinal data indicate that both GE (r = 0.54, p<0.001) and TIL abundance (p = 0.009) are stronger predictors for the reduction of tumor size, while low FOXP3+ was statistically significantly associated with an improved DFS (p = 0.027). In conclusion, GE analysis, TIL and FOXP3+ enumeration after short-term exposure to chemotherapy carry important predictive information in HR+/HER2- breast cancer at the neoadjuvant setting.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
Nyckelord
- biomarker
- breast cancer
- gene expression
- predictive
- tumor infiltrating lymphocytes
- Biology
- biomarker
- breast cancer
- gene expression
- predictive
- tumor infiltrating lymphocytes
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Matikas, Alexios
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Lövrot, John
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Ramberg, Anna
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Eriksson, Margar ...
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Lindsten, Theres ...
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Lekberg, Tobias
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visa fler...
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Hedenfalk, Ingri ...
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Loman, Niklas
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Bergh, Jonas
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Hatschek, Thomas
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Erlandsson, Ann, ...
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Foukakis, Theodo ...
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Oncoimmunology
- Av lärosätet
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Örebro universitet
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Karolinska Institutet
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