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Paternal age at chi...
Paternal age at childbirth and eating disorders in offspring
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- Javaras, K N (författare)
- Department of Psychiatry, University of North Carolina, Chapel Hill NC, USA
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- Rickert, M E (författare)
- Department of Psychological and Brain Sciences, Indiana University, Bloomington IN, USA
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- Thornton, L M (författare)
- Karolinska Institutet
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- Peat, C M (författare)
- Department of Psychiatry, University of North Carolina, Chapel Hill NC, USA; Department of Neurosurgery, University of North Carolina, Chapel Hill NC, USA
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- Baker, J H (författare)
- Department of Psychiatry, University of North Carolina, Chapel Hill NC, USA
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- Birgegård, A (författare)
- Karolinska Institutet
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- Norring, C (författare)
- Karolinska Institutet
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- Landén, M (författare)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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- Almqvist, C (författare)
- Karolinska Institutet
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- Larsson, Henrik, 1975- (författare)
- Karolinska Institutet
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- Lichtenstein, P (författare)
- Karolinska Institutet
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- Bulik, C M (författare)
- Karolinska Institutet
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- D'Onofrio, B M (författare)
- Karolinska Institutet
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- ISSN 1469-8978
- Stockholm : Cambridge University Press, 2017
- 2017
- Engelska.
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Ingår i: Psychological Medicine. - Stockholm : Cambridge University Press. - 0033-2917 .- 1469-8978. ; 47:3, s. 576-584
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Advanced paternal age at childbirth is associated with psychiatric disorders in offspring, including schizophrenia, bipolar disorder and autism. However, few studies have investigated paternal age's relationship with eating disorders in offspring. In a large, population-based cohort, we examined the association between paternal age and offspring eating disorders, and whether that association remains after adjustment for potential confounders (e.g. parental education level) that may be related to late/early selection into fatherhood and to eating disorder incidence.METHOD: Data for 2 276 809 individuals born in Sweden 1979-2001 were extracted from Swedish population and healthcare registers. The authors used Cox proportional hazards models to examine the effect of paternal age on the first incidence of healthcare-recorded anorexia nervosa (AN) and all eating disorders (AED) occurring 1987-2009. Models were adjusted for sex, birth order, maternal age at childbirth, and maternal and paternal covariates including country of birth, highest education level, and lifetime psychiatric and criminal history.RESULTS: Even after adjustment for covariates including maternal age, advanced paternal age was associated with increased risk, and younger paternal age with decreased risk, of AN and AED. For example, the fully adjusted hazard ratio for the 45+ years (v. the 25-29 years) paternal age category was 1.32 [95% confidence interval (CI) 1.14-1.53] for AN and 1.26 (95% CI 1.13-1.40) for AED.CONCLUSIONS: In this large, population-based cohort, paternal age at childbirth was positively associated with eating disorders in offspring, even after adjustment for potential confounders. Future research should further explore potential explanations for the association, including de novo mutations in the paternal germline.
Ämnesord
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Anorexia nervosa
- eating disorders
- paternal age
- Psykologi
- Psychology
- Psychiatry
- Psykiatri
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Javaras, K N
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Rickert, M E
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Thornton, L M
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Peat, C M
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Baker, J H
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Birgegård, A
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Norring, C
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Landén, M
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Almqvist, C
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Larsson, Henrik, ...
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Lichtenstein, P
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Bulik, C M
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D'Onofrio, B M
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Örebro universitet
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Karolinska Institutet