SwePub
Tyck till om SwePub Sök här!
Sök i LIBRIS databas

  Extended search

WFRF:(Liao Katherine P.)
 

Search: WFRF:(Liao Katherine P.) > (2014) > Boeing Heiner > Imputation and subs...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33

Wang, Zhaoming (author)
Zhu, Bin (author)
Zhang, Mingfeng (author)
show more...
Parikh, Hemang (author)
Jia, Jinping (author)
Chung, Charles C (author)
Sampson, Joshua N (author)
Hoskins, Jason W (author)
Hutchinson, Amy (author)
Burdette, Laurie (author)
Ibrahim, Abdisamad (author)
Hautman, Christopher (author)
Raj, Preethi S (author)
Abnet, Christian C (author)
Adjei, Andrew A (author)
Karolinska Institutet
Ahlbom, Anders (author)
Karolinska Institutet
Albanes, Demetrius (author)
Allen, Naomi E (author)
Ambrosone, Christine B (author)
Aldrich, Melinda (author)
Amiano, Pilar (author)
Amos, Christopher (author)
Andersson, Ulrika (author)
Umeå universitet,Onkologi
Andriole, Gerald (author)
Andrulis, Irene L (author)
Arici, Cecilia (author)
Arslan, Alan A (author)
Austin, Melissa A (author)
Baris, Dalsu (author)
Barkauskas, Donald A (author)
Bassig, Bryan A (author)
Beane Freeman, Laura E (author)
Berg, Christine D (author)
Berndt, Sonja I (author)
Bertazzi, Pier Alberto (author)
Biritwum, Richard B (author)
Black, Amanda (author)
Blot, William (author)
Boeing, Heiner (author)
Boffetta, Paolo (author)
Bolton, Kelly (author)
Boutron-Ruault, Marie-Christine (author)
Bracci, Paige M (author)
Brennan, Paul (author)
Brinton, Louise A (author)
Brotzman, Michelle (author)
Bueno-de-Mesquita, H Bas (author)
Buring, Julie E (author)
Butler, Mary Ann (author)
Cai, Qiuyin (author)
Cancel-Tassin, Geraldine (author)
Canzian, Federico (author)
Cao, Guangwen (author)
Caporaso, Neil E (author)
Carrato, Alfredo (author)
Carreon, Tania (author)
Carta, Angela (author)
Chang, Gee-Chen (author)
Chang, I-Shou (author)
Chang-Claude, Jenny (author)
Che, Xu (author)
Chen, Chien-Jen (author)
Chen, Chih-Yi (author)
Chen, Chung-Hsing (author)
Chen, Constance (author)
Chen, Kuan-Yu (author)
Chen, Yuh-Min (author)
Chokkalingam, Anand P (author)
Chu, Lisa W (author)
Clavel-Chapelon, Francoise (author)
Colditz, Graham A (author)
Colt, Joanne S (author)
Conti, David (author)
Cook, Michael B (author)
Cortessis, Victoria K (author)
Crawford, E David (author)
Cussenot, Olivier (author)
Davis, Faith G (author)
De Vivo, Immaculata (author)
Deng, Xiang (author)
Ding, Ti (author)
Dinney, Colin P (author)
Di Stefano, Anna Luisa (author)
Diver, W Ryan (author)
Duell, Eric J (author)
Elena, Joanne W (author)
Karolinska Institutet
Fan, Jin-Hu (author)
Feigelson, Heather Spencer (author)
Feychting, Maria (author)
Karolinska Institutet
Figueroa, Jonine D (author)
Flanagan, Adrienne M (author)
Fraumeni, Joseph F (author)
Freedman, Neal D (author)
Fridley, Brooke L (author)
Fuchs, Charles S (author)
Gago-Dominguez, Manuela (author)
Gallinger, Steven (author)
Gao, Yu-Tang (author)
Gapstur, Susan M (author)
Garcia-Closas, Montserrat (author)
Garcia-Closas, Reina (author)
Gastier-Foster, Julie M (author)
Gaziano, J Michael (author)
Gerhard, Daniela S (author)
Giffen, Carol A (author)
Giles, Graham G (author)
Gillanders, Elizabeth M (author)
Giovannucci, Edward L (author)
Goggins, Michael (author)
Gokgoz, Nalan (author)
Goldstein, Alisa M (author)
Gonzalez, Carlos (author)
Gorlick, Richard (author)
Greene, Mark H (author)
Gross, Myron (author)
Grossman, H Barton (author)
Grubb, Robert (author)
Gu, Jian (author)
Guan, Peng (author)
Haiman, Christopher A (author)
Hallmans, Göran (author)
Umeå universitet,Enheten för biobanksforskning,Näringsforskning
Hankinson, Susan E (author)
Harris, Curtis C (author)
Hartge, Patricia (author)
Hattinger, Claudia (author)
Hayes, Richard B (author)
He, Qincheng (author)
Helman, Lee (author)
Henderson, Brian E (author)
Henriksson, Roger (author)
Umeå universitet,Onkologi
Hoffman-Bolton, Judith (author)
Hohensee, Chancellor (author)
Holly, Elizabeth A (author)
Hong, Yun-Chul (author)
Hoover, Robert N (author)
Hosgood, H Dean (author)
Hsiao, Chin-Fu (author)
Hsing, Ann W (author)
Hsiung, Chao Agnes (author)
Hu, Nan (author)
Hu, Wei (author)
Hu, Zhibin (author)
Huang, Ming-Shyan (author)
Hunter, David J (author)
Inskip, Peter D (author)
Ito, Hidemi (author)
Jacobs, Eric J (author)
Jacobs, Kevin B (author)
Jenab, Mazda (author)
Ji, Bu-Tian (author)
Johansen, Christoffer (author)
Johansson, Mattias (author)
Umeå universitet,Institutionen för folkhälsa och klinisk medicin,International Agency for Research on Cancer (IARC-WHO), Lyon, France
Johnson, Alison (author)
Kaaks, Rudolf (author)
Kamat, Ashish M (author)
Kamineni, Aruna (author)
Karagas, Margaret (author)
Khanna, Chand (author)
Khaw, Kay-Tee (author)
Kim, Christopher (author)
Kim, In-Sam (author)
Kim, Jin Hee (author)
Kim, Yeul Hong (author)
Kim, Young-Chul (author)
Kim, Young Tae (author)
Kang, Chang Hyun (author)
Jung, Yoo Jin (author)
Kitahara, Cari M (author)
Klein, Alison P (author)
Klein, Robert (author)
Kogevinas, Manolis (author)
Koh, Woon-Puay (author)
Kohno, Takashi (author)
Kolonel, Laurence N (author)
Kooperberg, Charles (author)
Kratz, Christian P (author)
Krogh, Vittorio (author)
Kunitoh, Hideo (author)
Kurtz, Robert C (author)
Kurucu, Nilgun (author)
Lan, Qing (author)
Lathrop, Mark (author)
Lau, Ching C (author)
Lecanda, Fernando (author)
Lee, Kyoung-Mu (author)
Lee, Maxwell P (author)
Le Marchand, Loic (author)
Lerner, Seth P (author)
Li, Donghui (author)
Liao, Linda M (author)
Lim, Wei-Yen (author)
Lin, Dongxin (author)
Lin, Jie (author)
Lindstrom, Sara (author)
Linet, Martha S (author)
Lissowska, Jolanta (author)
Liu, Jianjun (author)
Ljungberg, Börje (author)
Umeå universitet,Urologi och andrologi,Njurcancer
Lloreta, Josep (author)
Lu, Daru (author)
Ma, Jing (author)
Malats, Nuria (author)
Mannisto, Satu (author)
Marina, Neyssa (author)
Mastrangelo, Giuseppe (author)
Matsuo, Keitaro (author)
McGlynn, Katherine A (author)
McKean-Cowdin, Roberta (author)
McNeill, Lorna H (author)
McWilliams, Robert R (author)
Melin, Beatrice S (author)
Umeå universitet,Onkologi,Kirurgi
Meltzer, Paul S (author)
Mensah, James E (author)
Miao, Xiaoping (author)
Michaud, Dominique S (author)
Mondul, Alison M (author)
Moore, Lee E (author)
Muir, Kenneth (author)
Niwa, Shelley (author)
Olson, Sara H (author)
Orr, Nick (author)
Panico, Salvatore (author)
Park, Jae Yong (author)
Patel, Alpa V (author)
Patino-Garcia, Ana (author)
Pavanello, Sofia (author)
Peeters, Petra H M (author)
Peplonska, Beata (author)
Peters, Ulrike (author)
Petersen, Gloria M (author)
Picci, Piero (author)
Pike, Malcolm C (author)
Porru, Stefano (author)
Prescott, Jennifer (author)
Pu, Xia (author)
Purdue, Mark P (author)
Qiao, You-Lin (author)
Rajaraman, Preetha (author)
Riboli, Elio (author)
Risch, Harvey A (author)
Rodabough, Rebecca J (author)
Rothman, Nathaniel (author)
Ruder, Avima M (author)
Ryu, Jeong-Seon (author)
Sanson, Marc (author)
Schned, Alan (author)
Schumacher, Fredrick R (author)
Schwartz, Ann G (author)
Schwartz, Kendra L (author)
Schwenn, Molly (author)
Scotlandi, Katia (author)
Seow, Adeline (author)
Serra, Consol (author)
Serra, Massimo (author)
Sesso, Howard D (author)
Severi, Gianluca (author)
Shen, Hongbing (author)
Shen, Min (author)
Shete, Sanjay (author)
Shiraishi, Kouya (author)
Shu, Xiao-Ou (author)
Siddiq, Afshan (author)
Sierrasesumaga, Luis (author)
Sierri, Sabina (author)
Loon Sihoe, Alan Dart (author)
Silverman, Debra T (author)
Simon, Matthias (author)
Southey, Melissa C (author)
Spector, Logan (author)
Spitz, Margaret (author)
Stampfer, Meir (author)
Stattin, Pär (author)
Umeå universitet,Uppsala universitet,Urologkirurgi,Urologi och andrologi
Stern, Mariana C (author)
Stevens, Victoria L (author)
Stolzenberg-Solomon, Rachael Z (author)
Stram, Daniel O (author)
Strom, Sara S (author)
Su, Wu-Chou (author)
Sund, Malin (author)
Sung, Sook Whan (author)
Swerdlow, Anthony (author)
Tan, Wen (author)
Tanaka, Hideo (author)
Tang, Wei (author)
Tang, Ze-Zhang (author)
Tardon, Adonina (author)
Tay, Evelyn (author)
Taylor, Philip R (author)
Tettey, Yao (author)
Thomas, David M (author)
Tirabosco, Roberto (author)
Tjonneland, Anne (author)
Tobias, Geoffrey S (author)
Toro, Jorge R (author)
Travis, Ruth C (author)
Trichopoulos, Dimitrios (author)
Troisi, Rebecca (author)
Truelove, Ann (author)
Tsai, Ying-Huang (author)
Tucker, Margaret A (author)
Tumino, Rosario (author)
Van Den Berg, David (author)
Van Den Eeden, Stephen K (author)
Vermeulen, Roel (author)
Vineis, Paolo (author)
Visvanathan, Kala (author)
Vogel, Ulla (author)
Wang, Chaoyu (author)
Wang, Chengfeng (author)
Wang, Junwen (author)
Wang, Sophia S (author)
Weiderpass, Elisabete (author)
Weinstein, Stephanie J (author)
Wentzensen, Nicolas (author)
Wheeler, William (author)
White, Emily (author)
Wiencke, John K (author)
Wolk, Alicja (author)
Wolpin, Brian M (author)
Wong, Maria Pik (author)
Wrensch, Margaret (author)
Wu, Chen (author)
Wu, Tangchun (author)
Wu, Xifeng (author)
Wu, Yi-Long (author)
Wunder, Jay S (author)
Xiang, Yong-Bing (author)
Xu, Jun (author)
Yang, Hannah P (author)
Yang, Pan-Chyr (author)
Yatabe, Yasushi (author)
Ye, Yuanqing (author)
Yeboah, Edward D (author)
Yin, Zhihua (author)
Ying, Chen (author)
Yu, Chong-Jen (author)
Yu, Kai (author)
Yuan, Jian-Min (author)
Zanetti, Krista A (author)
Zeleniuch-Jacquotte, Anne (author)
Zheng, Wei (author)
Zhou, Baosen (author)
Mirabello, Lisa (author)
Savage, Sharon A (author)
Kraft, Peter (author)
Chanock, Stephen J (author)
Yeager, Meredith (author)
Landi, Maria Terese (author)
Shi, Jianxin (author)
Chatterjee, Nilanjan (author)
Amundadottir, Laufey T (author)
show less...
 (creator_code:org_t)
2014-07-15
2014
English.
In: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 23:24, s. 6616-6633
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (association analysis based on subsets) across six distinct cancers in 34 248 cases and 45 036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single-nucleotide polymorphisms: five in the TERT gene (Region 1: rs7726159, P = 2.10 × 10(-39); Region 3: rs2853677, P = 3.30 × 10(-36) and PConditional = 2.36 × 10(-8); Region 4: rs2736098, P = 3.87 × 10(-12) and PConditional = 5.19 × 10(-6), Region 5: rs13172201, P = 0.041 and PConditional = 2.04 × 10(-6); and Region 6: rs10069690, P = 7.49 × 10(-15) and PConditional = 5.35 × 10(-7)) and one in the neighboring CLPTM1L gene (Region 2: rs451360; P = 1.90 × 10(-18) and PConditional = 7.06 × 10(-16)). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Find more in SwePub

By the author/editor
Wang, Zhaoming
Zhu, Bin
Zhang, Mingfeng
Parikh, Hemang
Jia, Jinping
Chung, Charles C
show more...
Sampson, Joshua ...
Hoskins, Jason W
Hutchinson, Amy
Burdette, Laurie
Ibrahim, Abdisam ...
Hautman, Christo ...
Raj, Preethi S
Abnet, Christian ...
Adjei, Andrew A
Ahlbom, Anders
Albanes, Demetri ...
Allen, Naomi E
Ambrosone, Chris ...
Aldrich, Melinda
Amiano, Pilar
Amos, Christophe ...
Andersson, Ulrik ...
Andriole, Gerald
Andrulis, Irene ...
Arici, Cecilia
Arslan, Alan A
Austin, Melissa ...
Baris, Dalsu
Barkauskas, Dona ...
Bassig, Bryan A
Beane Freeman, L ...
Berg, Christine ...
Berndt, Sonja I
Bertazzi, Pier A ...
Biritwum, Richar ...
Black, Amanda
Blot, William
Boeing, Heiner
Boffetta, Paolo
Bolton, Kelly
Boutron-Ruault, ...
Bracci, Paige M
Brennan, Paul
Brinton, Louise ...
Brotzman, Michel ...
Bueno-de-Mesquit ...
Buring, Julie E
Butler, Mary Ann
Cai, Qiuyin
Cancel-Tassin, G ...
Canzian, Federic ...
Cao, Guangwen
Caporaso, Neil E
Carrato, Alfredo
Carreon, Tania
Carta, Angela
Chang, Gee-Chen
Chang, I-Shou
Chang-Claude, Je ...
Che, Xu
Chen, Chien-Jen
Chen, Chih-Yi
Chen, Chung-Hsin ...
Chen, Constance
Chen, Kuan-Yu
Chen, Yuh-Min
Chokkalingam, An ...
Chu, Lisa W
Clavel-Chapelon, ...
Colditz, Graham ...
Colt, Joanne S
Conti, David
Cook, Michael B
Cortessis, Victo ...
Crawford, E Davi ...
Cussenot, Olivie ...
Davis, Faith G
De Vivo, Immacul ...
Deng, Xiang
Ding, Ti
Dinney, Colin P
Di Stefano, Anna ...
Diver, W Ryan
Duell, Eric J
Elena, Joanne W
Fan, Jin-Hu
Feigelson, Heath ...
Feychting, Maria
Figueroa, Jonine ...
Flanagan, Adrien ...
Fraumeni, Joseph ...
Freedman, Neal D
Fridley, Brooke ...
Fuchs, Charles S
Gago-Dominguez, ...
Gallinger, Steve ...
Gao, Yu-Tang
Gapstur, Susan M
Garcia-Closas, M ...
Garcia-Closas, R ...
Gastier-Foster, ...
Gaziano, J Micha ...
Gerhard, Daniela ...
Giffen, Carol A
Giles, Graham G
Gillanders, Eliz ...
Giovannucci, Edw ...
Goggins, Michael
Gokgoz, Nalan
Goldstein, Alisa ...
Gonzalez, Carlos
Gorlick, Richard
Greene, Mark H
Gross, Myron
Grossman, H Bart ...
Grubb, Robert
Gu, Jian
Guan, Peng
Haiman, Christop ...
Hallmans, Göran
Hankinson, Susan ...
Harris, Curtis C
Hartge, Patricia
Hattinger, Claud ...
Hayes, Richard B
He, Qincheng
Helman, Lee
Henderson, Brian ...
Henriksson, Roge ...
Hoffman-Bolton, ...
Hohensee, Chance ...
Holly, Elizabeth ...
Hong, Yun-Chul
Hoover, Robert N
Hosgood, H Dean
Hsiao, Chin-Fu
Hsing, Ann W
Hsiung, Chao Agn ...
Hu, Nan
Hu, Wei
Hu, Zhibin
Huang, Ming-Shya ...
Hunter, David J
Inskip, Peter D
Ito, Hidemi
Jacobs, Eric J
Jacobs, Kevin B
Jenab, Mazda
Ji, Bu-Tian
Johansen, Christ ...
Johansson, Matti ...
Johnson, Alison
Kaaks, Rudolf
Kamat, Ashish M
Kamineni, Aruna
Karagas, Margare ...
Khanna, Chand
Khaw, Kay-Tee
Kim, Christopher
Kim, In-Sam
Kim, Jin Hee
Kim, Yeul Hong
Kim, Young-Chul
Kim, Young Tae
Kang, Chang Hyun
Jung, Yoo Jin
Kitahara, Cari M
Klein, Alison P
Klein, Robert
Kogevinas, Manol ...
Koh, Woon-Puay
Kohno, Takashi
Kolonel, Laurenc ...
Kooperberg, Char ...
Kratz, Christian ...
Krogh, Vittorio
Kunitoh, Hideo
Kurtz, Robert C
Kurucu, Nilgun
Lan, Qing
Lathrop, Mark
Lau, Ching C
Lecanda, Fernand ...
Lee, Kyoung-Mu
Lee, Maxwell P
Le Marchand, Loi ...
Lerner, Seth P
Li, Donghui
Liao, Linda M
Lim, Wei-Yen
Lin, Dongxin
Lin, Jie
Lindstrom, Sara
Linet, Martha S
Lissowska, Jolan ...
Liu, Jianjun
Ljungberg, Börje
Lloreta, Josep
Lu, Daru
Ma, Jing
Malats, Nuria
Mannisto, Satu
Marina, Neyssa
Mastrangelo, Giu ...
Matsuo, Keitaro
McGlynn, Katheri ...
McKean-Cowdin, R ...
McNeill, Lorna H
McWilliams, Robe ...
Melin, Beatrice ...
Meltzer, Paul S
Mensah, James E
Miao, Xiaoping
Michaud, Dominiq ...
Mondul, Alison M
Moore, Lee E
Muir, Kenneth
Niwa, Shelley
Olson, Sara H
Orr, Nick
Panico, Salvator ...
Park, Jae Yong
Patel, Alpa V
Patino-Garcia, A ...
Pavanello, Sofia
Peeters, Petra H ...
Peplonska, Beata
Peters, Ulrike
Petersen, Gloria ...
Picci, Piero
Pike, Malcolm C
Porru, Stefano
Prescott, Jennif ...
Pu, Xia
Purdue, Mark P
Qiao, You-Lin
Rajaraman, Preet ...
Riboli, Elio
Risch, Harvey A
Rodabough, Rebec ...
Rothman, Nathani ...
Ruder, Avima M
Ryu, Jeong-Seon
Sanson, Marc
Schned, Alan
Schumacher, Fred ...
Schwartz, Ann G
Schwartz, Kendra ...
Schwenn, Molly
Scotlandi, Katia
Seow, Adeline
Serra, Consol
Serra, Massimo
Sesso, Howard D
Severi, Gianluca
Shen, Hongbing
Shen, Min
Shete, Sanjay
Shiraishi, Kouya
Shu, Xiao-Ou
Siddiq, Afshan
Sierrasesumaga, ...
Sierri, Sabina
Loon Sihoe, Alan ...
Silverman, Debra ...
Simon, Matthias
Southey, Melissa ...
Spector, Logan
Spitz, Margaret
Stampfer, Meir
Stattin, Pär
Stern, Mariana C
Stevens, Victori ...
Stolzenberg-Solo ...
Stram, Daniel O
Strom, Sara S
Su, Wu-Chou
Sund, Malin
Sung, Sook Whan
Swerdlow, Anthon ...
Tan, Wen
Tanaka, Hideo
Tang, Wei
Tang, Ze-Zhang
Tardon, Adonina
Tay, Evelyn
Taylor, Philip R
Tettey, Yao
Thomas, David M
Tirabosco, Rober ...
Tjonneland, Anne
Tobias, Geoffrey ...
Toro, Jorge R
Travis, Ruth C
Trichopoulos, Di ...
Troisi, Rebecca
Truelove, Ann
Tsai, Ying-Huang
Tucker, Margaret ...
Tumino, Rosario
Van Den Berg, Da ...
Van Den Eeden, S ...
Vermeulen, Roel
Vineis, Paolo
Visvanathan, Kal ...
Vogel, Ulla
Wang, Chaoyu
Wang, Chengfeng
Wang, Junwen
Wang, Sophia S
Weiderpass, Elis ...
Weinstein, Steph ...
Wentzensen, Nico ...
Wheeler, William
White, Emily
Wiencke, John K
Wolk, Alicja
Wolpin, Brian M
Wong, Maria Pik
Wrensch, Margare ...
Wu, Chen
Wu, Tangchun
Wu, Xifeng
Wu, Yi-Long
Wunder, Jay S
Xiang, Yong-Bing
Xu, Jun
Yang, Hannah P
Yang, Pan-Chyr
Yatabe, Yasushi
Ye, Yuanqing
Yeboah, Edward D
Yin, Zhihua
Ying, Chen
Yu, Chong-Jen
Yu, Kai
Yuan, Jian-Min
Zanetti, Krista ...
Zeleniuch-Jacquo ...
Zheng, Wei
Zhou, Baosen
Mirabello, Lisa
Savage, Sharon A
Kraft, Peter
Chanock, Stephen ...
Yeager, Meredith
Landi, Maria Ter ...
Shi, Jianxin
Chatterjee, Nila ...
Amundadottir, La ...
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Cancer and Oncol ...
Articles in the publication
Human Molecular ...
By the university
Uppsala University
Umeå University
Karolinska Institutet

Search outside SwePub

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view