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Dietary folate inta...
Dietary folate intake and pancreatic cancer risk : Results from the European prospective investigation into cancer and nutrition
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- Park, Jin Young (author)
- International Agency for Research on Cancer, World Health Organization
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- Bueno-de-Mesquita, H. Bas (author)
- University Medical Center Utrecht,Imperial College London,National Institute for Public Health and the Environment (RIVM)
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- Ferrari, Pietro (author)
- International Agency for Research on Cancer, World Health Organization
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- Weiderpass, Elisabete (author)
- Karolinska Institute,Karolinska Institutet,Folkhälsan Research Center,UiT The Arctic University of Norway, Tromsø,Cancer Registry of Norway, Institute of Population-Based Cancer Research
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- de Batlle, Jordi (author)
- CIBER Enfermedades Respiratorias (CIBERES)
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- Tjonneland, Anne (author)
- Danish Cancer Society
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- Kyro, Cecilie (author)
- Danish Cancer Society
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- Rebours, Vinciane (author)
- Beaujon Hospital,Paris Diderot University
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- Boutron-Ruault, Marie-Christine (author)
- Stabilite genetique et oncogenese,University of Paris-Saclay
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- Mancini, Francesca Romana (author)
- University of Paris-Saclay,Stabilite genetique et oncogenese
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- Katzke, Verena (author)
- German Cancer Research Centre
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- Kuehn, Tilman (author)
- German Cancer Research Centre
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- Boeing, Heiner (author)
- German Institute of Human Nutrition
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- Trichopoulou, Antonia (author)
- Hellenic Health Foundation, Athens
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- La Vecchia, Carlo (author)
- University of Milan,Hellenic Health Foundation, Athens
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- Kritikou, Maria (author)
- Hellenic Health Foundation, Athens
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Masala, Giovanna (author)
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- Pala, Valeria (author)
- Istituto Nazionale dei Tumori
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Tumino, Rosario (author)
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- Panico, Salvatore (author)
- University of Naples Federico II
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- Peeters, Petra H. (author)
- University Medical Center Utrecht,Imperial College London
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- Skeie, Guri (author)
- UiT The Arctic University of Norway, Tromsø
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Merino, Susana (author)
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- Duell, Eric J. (author)
- Bellvitge University Hospital-IDIBELL
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- Rodriguez-Barranco, Miguel (author)
- CIBER Epidemiology and Public Health (CIBERESP),University of Granada
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- Dorronsoro, Miren (author)
- CIBER Epidemiology and Public Health (CIBERESP)
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- Chirlaque, Maria-Dolores (author)
- University of Murcia,CIBER Epidemiology and Public Health (CIBERESP),Murcia Regional Health Council
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- Ardanaz, Eva (author)
- CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)
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- Gylling, Björn, 1978- (author)
- Umeå University,Umeå universitet,Patologi
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- Schneede, Jörn (author)
- Umeå University,Umeå universitet,Farmakologi
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- Ericson, Ulrika (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Sternby, Hanna (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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- Khaw, Kay-Tee (author)
- University of Cambridge
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- Bradbury, Kathryn E. (author)
- University of Oxford
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- Huybrechts, Inge (author)
- International Agency for Research on Cancer, World Health Organization
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- Aune, Dagfinn (author)
- Imperial College London,Bjørknes University College
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- Vineis, Paolo (author)
- Imperial College London
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- Slimani, Nadia (author)
- International Agency for Research on Cancer, World Health Organization
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(creator_code:org_t)
- 2018-12-21
- 2019
- English.
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In: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 144:7, s. 1511-1521
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Pancreatic cancer (PC) has an exceptionally low survival rate and primary prevention strategies are limited. Folate plays an important role in one-carbon metabolism and has been associated with the risk of several cancers, but not consistently with PC risk. We aimed to investigate the association between dietary folate intake and PC risk, using the standardised folate database across 10 European countries. A total of 477,206 participants were followed up for 11 years, during which 865 incident primary PC cases were recorded. Folate intake was energy-adjusted using the residual method. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. In multivariable analyses stratified by age, sex, study centre and adjusted for energy intake, smoking status, BMI, educational level, diabetes status, supplement use and dietary fibre intake, we found no significant association between folate intake and PC risk: the HR of PC risk for those in the highest quartile of folate intake (>= 353 mu g/day) compared to the lowest (<241 mu g/day) was 0.81 (95% CI: 0.51, 1.31; p(trend) = 0.38). In current smokers, a positive trend was observed in PC risk across folate quartiles [HR = 4.42 (95% CI: 1.05, 18.62) for >= 353 mu g/day vs. <241 mu g/day, p(trend) = 0.01]. Nonetheless, there was no significant interaction between smoking and dietary folate intake (p(interaction) = 0.99). We found no association between dietary folate intake and PC risk in this large European study.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- dietary folate intake
- pancreatic cancer
- EPIC study
- dietary folate intake
- EPIC study
- pancreatic cancer
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Park, Jin Young
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Bueno-de-Mesquit ...
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Ferrari, Pietro
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Weiderpass, Elis ...
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de Batlle, Jordi
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Tjonneland, Anne
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show more...
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Kyro, Cecilie
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Rebours, Vincian ...
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Boutron-Ruault, ...
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Mancini, Frances ...
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Katzke, Verena
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Kuehn, Tilman
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Boeing, Heiner
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Trichopoulou, An ...
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La Vecchia, Carl ...
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Kritikou, Maria
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Masala, Giovanna
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Pala, Valeria
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Tumino, Rosario
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Panico, Salvator ...
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Peeters, Petra H ...
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Skeie, Guri
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Merino, Susana
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Duell, Eric J.
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Rodriguez-Barran ...
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Dorronsoro, Mire ...
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Chirlaque, Maria ...
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Ardanaz, Eva
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Gylling, Björn, ...
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Schneede, Jörn
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Ericson, Ulrika
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Sternby, Hanna
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Khaw, Kay-Tee
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Bradbury, Kathry ...
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Huybrechts, Inge
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Aune, Dagfinn
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Vineis, Paolo
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Slimani, Nadia
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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International Jo ...
- By the university
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Umeå University
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Karolinska Institutet
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Lund University