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Genome-wide associa...
Genome-wide association study identifies new prostate cancer susceptibility loci
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Schumacher, Fredrick R. (author)
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Berndt, Sonja I. (author)
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Siddiq, Afshan (author)
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show more...
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Jacobs, Kevin B. (author)
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Wang, Zhaoming (author)
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Lindstrom, Sara (author)
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Stevens, Victoria L. (author)
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Chen, Constance (author)
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Mondul, Alison M. (author)
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Travis, Ruth C. (author)
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Stram, Daniel O. (author)
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Eeles, Rosalind A. (author)
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Easton, Douglas F. (author)
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Giles, Graham (author)
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Hopper, John L. (author)
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Neal, David E. (author)
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Hamdy, Freddie C. (author)
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Donovan, Jenny L. (author)
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Muir, Kenneth (author)
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Al Olama, Ali Amin (author)
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Kote-Jarai, Zsofia (author)
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Guy, Michelle (author)
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Severi, Gianluca (author)
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- Gronberg, Henrik (author)
- Karolinska Institutet
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Isaacs, William B. (author)
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- Karlsson, Robert (author)
- Karolinska Institutet
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- Wiklund, Fredrik (author)
- Karolinska Institutet
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Xu, Jianfeng (author)
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Allen, Naomi E. (author)
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Andriole, Gerald L. (author)
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Barricarte, Aurelio (author)
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Boeing, Heiner (author)
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Bueno-de-Mesquita, H. Bas (author)
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Crawford, E. David (author)
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Diver, W. Ryan (author)
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Gonzalez, Carlos A. (author)
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Gaziano, J. Michael (author)
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Giovannucci, Edward L. (author)
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- Johansson, Mattias (author)
- Umeå universitet,Urologi och andrologi,International Agency for Research on Cancer (IARC), Lyon, France
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Le Marchand, Loic (author)
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Ma, Jing (author)
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Sieri, Sabina (author)
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- Stattin, Pär (author)
- Umeå universitet,Urologi och andrologi
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Stampfer, Meir J. (author)
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Tjonneland, Anne (author)
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Vineis, Paolo (author)
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Virtamo, Jarmo (author)
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Vogel, Ulla (author)
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Weinstein, Stephanie J. (author)
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Yeager, Meredith (author)
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Thun, Michael J. (author)
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Kolonel, Laurence N. (author)
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Henderson, Brian E. (author)
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Albanes, Demetrius (author)
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Hayes, Richard B. (author)
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Feigelson, Heather Spencer (author)
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Riboli, Elio (author)
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Hunter, David J. (author)
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Chanock, Stephen J. (author)
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Haiman, Christopher A. (author)
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Kraft, Peter (author)
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(creator_code:org_t)
- 2011-07-08
- 2011
- English.
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In: Human Molecular Genetics. - London : IRL Press. - 0964-6906 .- 1460-2083. ; 20:19, s. 3867-3875
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- Prostate cancer (PrCa) is the most common non-skin cancer diagnosed among males in developed countries and the second leading cause of cancer mortality, yet little is known regarding its etiology and factors that influence clinical outcome. Genome-wide association studies (GWAS) of PrCa have identified at least 30 distinct loci associated with small differences in risk. We conducted a GWAS in 2782 advanced PrCa cases (Gleason grade >= 8 or tumor stage C/D) and 4458 controls with 571 243 single nucleotide polymorphisms (SNPs). Based on in silico replication of 4679 SNPs (Stage 1, P < 0.02) in two published GWAS with 7358 PrCa cases and 6732 controls, we identified a new susceptibility locus associated with overall PrCa risk at 2q37.3 (rs2292884, P = 4.3 x 10(-8)). We also confirmed a locus suggested by an earlier GWAS at 12q13 (rs902774, P = 8.6 x 10(-9)). The estimated per-allele odds ratios for these loci (1.14 for rs2292884 and 1.17 for rs902774) did not differ between advanced and non-advanced PrCa (case-only test for heterogeneity P = 0.72 and P = 0.61, respectively). Further studies will be needed to assess whether these or other loci are differentially associated with PrCa subtypes.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Schumacher, Fred ...
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Berndt, Sonja I.
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Siddiq, Afshan
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Jacobs, Kevin B.
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Wang, Zhaoming
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Lindstrom, Sara
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show more...
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Stevens, Victori ...
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Chen, Constance
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Mondul, Alison M ...
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Travis, Ruth C.
-
Stram, Daniel O.
-
Eeles, Rosalind ...
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Easton, Douglas ...
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Giles, Graham
-
Hopper, John L.
-
Neal, David E.
-
Hamdy, Freddie C ...
-
Donovan, Jenny L ...
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Muir, Kenneth
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Al Olama, Ali Am ...
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Kote-Jarai, Zsof ...
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Guy, Michelle
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Severi, Gianluca
-
Gronberg, Henrik
-
Isaacs, William ...
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Karlsson, Robert
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Wiklund, Fredrik
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Xu, Jianfeng
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Allen, Naomi E.
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Andriole, Gerald ...
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Barricarte, Aure ...
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Boeing, Heiner
-
Bueno-de-Mesquit ...
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Crawford, E. Dav ...
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Diver, W. Ryan
-
Gonzalez, Carlos ...
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Gaziano, J. Mich ...
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Giovannucci, Edw ...
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Johansson, Matti ...
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Le Marchand, Loi ...
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Ma, Jing
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Sieri, Sabina
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Stattin, Pär
-
Stampfer, Meir J ...
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Tjonneland, Anne
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Vineis, Paolo
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Virtamo, Jarmo
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Vogel, Ulla
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Weinstein, Steph ...
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Yeager, Meredith
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Thun, Michael J.
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Kolonel, Laurenc ...
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Henderson, Brian ...
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Albanes, Demetri ...
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Hayes, Richard B ...
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Feigelson, Heath ...
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Riboli, Elio
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Hunter, David J.
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Chanock, Stephen ...
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Haiman, Christop ...
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Kraft, Peter
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
- Articles in the publication
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Human Molecular ...
- By the university
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Umeå University
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Karolinska Institutet