Sökning: WFRF:(Sundelin G.)
> Olsson Mats J. >
Behavioral and neur...
Behavioral and neural correlates to multisensory detection of sick humans
-
Regenbogen, Christina (författare)
-
- Axelsson, John (författare)
- Stockholms universitet,Stressforskningsinstitutet,Karolinska Institutet, Sweden
-
- Lasselin, Julie (författare)
- Stockholms universitet,Stressforskningsinstitutet,Karolinska Institutet, Sweden; Universitätsklinikum Essen, Germany
-
visa fler...
-
- Porada, Danja K. (författare)
- Karolinska Institutet
-
- Sundelin, Tina (författare)
- Stockholms universitet,Biologisk psykologi,Karolinska Institutet, Sweden
-
- Peter, Moa G. (författare)
- Karolinska Institutet
-
- Lekander, Mats (författare)
- Karolinska Institutet,Stockholms universitet,Stressforskningsinstitutet,Karolinska Institute, Sweden
-
- Lundström, Johan N. (författare)
- Karolinska Institutet
-
- Olsson, Mats J. (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- 2017-05-22
- 2017
- Engelska.
-
Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 114:24, s. 6400-6405
- Relaterad länk:
-
https://www.pnas.org...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Throughout human evolution, infectious diseases have been a primary cause of death. Detection of subtle cues indicating sickness and avoidance of sick conspecifics would therefore be an adaptive way of coping with an environment fraught with pathogens. This study determines how humans perceive and integrate early cues of sickness in conspecifics sampled just hours after the induction of immune system activation, and the underlying neural mechanisms for this detection. In a double-blind placebo-controlled crossover design, the immune system in 22 sample donors was transiently activated with an endotoxin injection [lipopolysaccharide (LPS)]. Facial photographs and body odor samples were taken from the same donors when sick (LPS-injected) and when healthy (saline-injected) and subsequently were presented to a separate group of participants (n = 30) who rated their liking of the presented person during fMRI scanning. Faces were less socially desirable when sick, and sick body odors tended to lower liking of the faces. Sickness status presented by odor and facial photograph resulted in increased neural activation of odor-and faceperception networks, respectively. A superadditive effect of olfactory-visual integration of sickness cues was found in the intraparietal sulcus, which was functionally connected to core areas of multisensory integration in the superior temporal sulcus and orbitofrontal cortex. Taken together, the results outline a disease-avoidance model in which neural mechanisms involved in the detection of disease cues and multisensory integration are vital parts.
Ämnesord
- NATURVETENSKAP -- Annan naturvetenskap (hsv//swe)
- NATURAL SCIENCES -- Other Natural Sciences (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Nyckelord
- body odor
- lipopolysaccharide
- endotoxin
- sickness cues
- disease avoidance
- Psychology
- psykologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas