Search: WFRF:(Alves Alexessander Couto)
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Genome-wide Associa...
Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length
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- Li, Chen (author)
- Glenfield Hospital,University of Cambridge
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- Stoma, Svetlana (author)
- Karolinska Institutet
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Lotta, Luca A. (author)
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show more...
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Warner, Sophie (author)
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Albrecht, Eva (author)
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Allione, Alessandra (author)
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Arp, Pascal P. (author)
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Broer, Linda (author)
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Buxton, Jessica L. (author)
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Da Silva Couto Alves, Alexessander (author)
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Deelen, Joris (author)
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Fedko, Iryna O. (author)
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Gordon, Scott D. (author)
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Jiang, Tao (author)
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- Karlsson, Robert (author)
- Karolinska Institutet
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Kerrison, Nicola (author)
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Loe, Taylor K. (author)
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Mangino, Massimo (author)
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Milaneschi, Yuri (author)
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Miraglio, Benjamin (author)
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Pervjakova, Natalia (author)
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Russo, Alessia (author)
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Surakka, Ida (author)
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van der Spek, Ashley (author)
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Verhoeven, Josine E. (author)
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Amin, Najaf (author)
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Beekman, Marian (author)
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Blakemore, Alexandra I. (author)
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Canzian, Federico (author)
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Hamby, Stephen E. (author)
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Hottenga, Jouke-Jan (author)
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Jones, Peter D. (author)
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Jousilahti, Pekka (author)
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Mägi, Reedik (author)
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Medland, Sarah E. (author)
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Montgomery, Grant W. (author)
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Nyholt, Dale R. (author)
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- Perola, Markus (author)
- Finnish National Institute for Health and Welfare,University of Helsinki
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Pietiläinen, Kirsi H. (author)
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Salomaa, Veikko (author)
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Sillanpää, Elina (author)
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Suchiman, H. Eka (author)
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van Heemst, Diana (author)
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Willemsen, Gonneke (author)
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Agudo, Antonio (author)
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Boeing, Heiner (author)
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Boomsma, Dorret I. (author)
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Chirlaque, Maria-Dolores (author)
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Fagherazzi, Guy (author)
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Ferrari, Pietro (author)
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- Franks, Paul W. (author)
- Umeå University,Lund University,Lunds universitet,Umeå universitet,Näringsforskning,Department of Clinical Sciences, Clinical Research Center, Skåne University Hospital, Lund University, 20502 Malmö Sweden,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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Gieger, Christian (author)
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- Eriksson, Johan Gunnar (author)
- National University of Singapore,Helsinki University Central Hospital,University of Helsinki
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Gunter, Marc (author)
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Hagg, Sara (author)
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Hovatta, Iiris (author)
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Imaz, Liher (author)
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Kaprio, Jaakko (author)
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Kaaks, Rudolf (author)
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Key, Timothy (author)
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Krogh, Vittorio (author)
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Martin, Nicholas G. (author)
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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Metspalu, Andres (author)
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Moreno, Concha (author)
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Onland-Moret, N. Charlotte (author)
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- Nilsson, Peter (author)
- Skåne University Hospital
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Ong, Ken K. (author)
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Overvad, Kim (author)
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Palli, Domenico (author)
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Panico, Salvatore (author)
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- Pedersen, Nancy L. (author)
- Karolinska Institutet
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Penninx, Brenda W. J. H. (author)
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Quirós, J. Ramón (author)
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Riitta Jarvelin, Marjo (author)
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Rodríguez-Barranco, Miguel (author)
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Scott, Robert A. (author)
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Severi, Gianluca (author)
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Slagboom, P. Eline (author)
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Spector, Tim D. (author)
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Tjonneland, Anne (author)
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Trichopoulou, Antonia (author)
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Tumino, Rosario (author)
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Uitterlinden, André G. (author)
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van der Schouw, Yvonne T. (author)
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van Duijn, Cornelia M. (author)
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Weiderpass, Elisabete (author)
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Denchi, Eros Lazzerini (author)
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Matullo, Giuseppe (author)
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Butterworth, Adam S. (author)
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Danesh, John (author)
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Samani, Nilesh J. (author)
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Wareham, Nicholas J. (author)
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Nelson, Christopher P. (author)
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Langenberg, Claudia (author)
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- Codd, Veryan (author)
- University of Leicester,Glenfield Hospital
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(creator_code:org_t)
- CELL PRESS, 2020
- 2020
- English.
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In: American Journal of Human Genetics. - : CELL PRESS. - 0002-9297 .- 1537-6605. ; 106:3, s. 389-404
- Related links:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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http://www.cell.com/...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Subject headings
Close
- Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed association results across large-scale European-descent studies including up to 78,592 individuals. We identify 49 genomic regions at a false dicovery rate (FDR) < 0.05 threshold and prioritize genes at 31, with five highlighting nucleotide metabolism as an important regulator of LTL. We report six genome-wide significant loci in or near SENP7, MOB1B, CARMIL1 , PRRC2A, TERF2, and RFWD3, and our results support recently identified PARP1, POT1, ATM, and MPHOSPH6 loci. Phenome-wide analyses in >350,000 UK Biobank participants suggest that genetically shorter telomere length increases the risk of hypothyroidism and decreases the risk of thyroid cancer, lymphoma, and a range of proliferative conditions. Our results replicate previously reported associations with increased risk of coronary artery disease and lower risk for multiple cancer types. Our findings substantially expand current knowledge on genes that regulate LTL and their impact on human health and disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- telomere length
- biological aging
- Mendelian randomisation
- age-related disease
- age-related disease
- biological aging
- Mendelian randomisation
- telomere length
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Li, Chen
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Stoma, Svetlana
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Lotta, Luca A.
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Warner, Sophie
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Albrecht, Eva
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Allione, Alessan ...
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show more...
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Arp, Pascal P.
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Broer, Linda
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Buxton, Jessica ...
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Da Silva Couto A ...
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Deelen, Joris
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Fedko, Iryna O.
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Gordon, Scott D.
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Jiang, Tao
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Karlsson, Robert
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Kerrison, Nicola
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Loe, Taylor K.
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Mangino, Massimo
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Milaneschi, Yuri
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Miraglio, Benjam ...
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Pervjakova, Nata ...
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Russo, Alessia
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Surakka, Ida
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van der Spek, As ...
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Verhoeven, Josin ...
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Amin, Najaf
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Beekman, Marian
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Blakemore, Alexa ...
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Canzian, Federic ...
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Hamby, Stephen E ...
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Hottenga, Jouke- ...
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Jones, Peter D.
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Jousilahti, Pekk ...
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Mägi, Reedik
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Medland, Sarah E ...
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Montgomery, Gran ...
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Nyholt, Dale R.
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Perola, Markus
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Pietiläinen, Kir ...
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Salomaa, Veikko
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Sillanpää, Elina
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Suchiman, H. Eka
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van Heemst, Dian ...
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Willemsen, Gonne ...
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Agudo, Antonio
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Boeing, Heiner
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Boomsma, Dorret ...
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Chirlaque, Maria ...
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Fagherazzi, Guy
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Ferrari, Pietro
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Franks, Paul W.
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Gieger, Christia ...
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Eriksson, Johan ...
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Gunter, Marc
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Hagg, Sara
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Hovatta, Iiris
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Imaz, Liher
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Kaprio, Jaakko
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Kaaks, Rudolf
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Key, Timothy
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Krogh, Vittorio
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Martin, Nicholas ...
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Melander, Olle
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Metspalu, Andres
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Moreno, Concha
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Onland-Moret, N. ...
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Nilsson, Peter
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Ong, Ken K.
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Overvad, Kim
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Palli, Domenico
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Panico, Salvator ...
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Pedersen, Nancy ...
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Penninx, Brenda ...
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Quirós, J. Ramón
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Riitta Jarvelin, ...
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Rodríguez-Barran ...
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Scott, Robert A.
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Severi, Gianluca
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Slagboom, P. Eli ...
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Spector, Tim D.
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Tjonneland, Anne
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Trichopoulou, An ...
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Tumino, Rosario
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Uitterlinden, An ...
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van der Schouw, ...
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van Duijn, Corne ...
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Weiderpass, Elis ...
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Denchi, Eros Laz ...
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Matullo, Giusepp ...
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Butterworth, Ada ...
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Danesh, John
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Samani, Nilesh J ...
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Wareham, Nichola ...
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Nelson, Christop ...
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Langenberg, Clau ...
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Codd, Veryan
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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American Journal ...
- By the university
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Umeå University
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Lund University
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Karolinska Institutet