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Dopamine-related re...
Dopamine-related receptors, substance dependence, behavioral problems and personality among juvenile delinquents
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- Ruchkin, Vladislav V., 1969- (författare)
- Uppsala universitet,Barn- och ungdomspsykiatri,Yale Univ, Sch Med, Child Study Ctr, New Haven, CT USA.;Sater Forens Psychiat Clin, Sater, Sweden.
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- Koposov, Roman (författare)
- UiT Arctic Univ Norway, Reg Ctr Child & Youth Mental Hlth & Child Welf, Tromso, Norway.
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- Oreland, Lars (författare)
- Uppsala universitet,Institutionen för neurovetenskap
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- af Klinteberg, Britt (författare)
- Stockholms universitet,Centrum för forskning om ojämlikhet i hälsa (CHESS),Biologisk psykologi,Stockholm Univ, Dept Psychol, Stockholm, Sweden.;Stockholm Univ, Dept Publ Hlth Sci, Stockholm, Sweden.
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- Grigorenko, Elena L. (författare)
- Yale Univ, Sch Med, Child Study Ctr, New Haven, CT USA.;Univ Houston, Developmentai Cognit & Behav Neurosci & Clin Psyc, Houston, TX USA.;Baylor Coll Med, Mol & Human Genet, Houston, TX 77030 USA.;St Petersburg Univ, Lab Translat Dev Sci, St Petersburg, Russia.
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- Engelska.
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Ingår i: Personality and Individual Differences. - : Elsevier BV. - 0191-8869 .- 1873-3549. ; 169
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The objective was two-fold: to examine possible associations between dopamine-related genetic polymorphisms and (1) substance dependence; and (2) self-reported psychiatric disturbances, behavioral problems, and personality. Genotyping of single nucleotide polymorphisms (SNP: s) in COMT, DAT and DRD4 was conducted in 174 Russian male juvenile inmates (14–18 years of age) subdivided into having a diagnosis of substance dependence or not, as assessed by using K-SADS-PL. The inmates completed several self-reports assessing psychiatric symptoms (CPTS-RI, BDI), behavioral problems (YSR), and personality traits (TCI). Results revealed that juveniles meeting the criteria for substance dependence differed significantly from their counterparts in four polymorphisms, namely COMT rs737865, DAT rs6347, DRD4 C_1611535 and DRD4 exon III; and exact binary regression analysis indicated a highly significant association between the DRD4 C_1611535 GG genotype and substance dependence. One-way ANOVA tests further showed this gene polymorphism variant to be significantly associated with higher levels of posttraumatic stress, thought problems, aggressive behavior, and personality traits indicating antisocial personality disturbances, as compared with the other gene polymorphism variants. In conclusion, the results underscore the role of the DRD4 polymorphism C_1611535 GG genotype for substance dependence, and suggest its associations with different self-reported phenotype characteristics.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- dopamine
- substance dependence
- behavioral problems
- personality
- juvenile delinquents
- folkhälsovetenskap
- Public Health Sciences
- Psychology
- psykologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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