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A Mendelian randomi...
A Mendelian randomization study of circulating uric acid and type 2 diabetes.
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Sluijs, Ivonne (author)
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Holmes, Michael V (author)
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van der Schouw, Yvonne T (author)
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show more...
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Beulens, Joline Wj (author)
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Asselbergs, Folkert W (author)
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Huerta, José María (author)
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Palmer, Tom M (author)
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Arriola, Larraitz (author)
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Balkau, Beverley (author)
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Barricarte, Aurelio (author)
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Boeing, Heiner (author)
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Clavel-Chapelon, Françoise (author)
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Fagherazzi, Guy (author)
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- Franks, Paul (author)
- Umeå universitet,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Medicin
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Gavrila, Diana (author)
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Kaaks, Rudolf (author)
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Khaw, Kay Tee (author)
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Kühn, Tilman (author)
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Molina-Montes, Esther (author)
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Mortensen, Lotte Maxild (author)
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- Nilsson, Peter (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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Overvad, Kim (author)
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Palli, Domenico (author)
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Panico, Salvatore (author)
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Quirós, J Ramón (author)
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- Rolandsson, Olov (author)
- Umeå universitet,Allmänmedicin
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Sacerdote, Carlotta (author)
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Sala, Núria (author)
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Schmidt, Julie A (author)
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Scott, Robert A (author)
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Sieri, Sabina (author)
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Slimani, Nadia (author)
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Spijkerman, Annemieke Mw (author)
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Tjonneland, Anne (author)
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Travis Dphil, Ruth C (author)
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Tumino, Rosario (author)
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van der A, Daphne L (author)
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Sharp, Stephen J (author)
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Forouhi, Nita G (author)
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Langenberg, Claudia (author)
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Riboli, Elio (author)
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Wareham, Nicholas J (author)
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(creator_code:org_t)
- 2015-04-27
- 2015
- English.
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In: Diabetes. - : American Diabetes Association. - 1939-327X .- 0012-1797. ; 64:8, s. 3028-3036
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://diabetes.dia...
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https://lup.lub.lu.s...
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https://doi.org/10.2...
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https://urn.kb.se/re...
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Abstract
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- We aimed to investigate the causal effect of circulating uric acid concentrations on type 2 diabetes risk. A Mendelian randomization study was performed using a genetic score with 24 uric acid associated loci. We used data of the EPIC-InterAct case-cohort study, comprising 24,265 individuals of European ancestry from eight European countries. During a mean (SD) follow-up of 10 (4) years, 10,576 verified incident type 2 diabetes cases were ascertained. Higher uric acid associated with higher diabetes risk following adjustment for confounders, with a HR of 1.20 (95%CI: 1.11,1.30) per 59.48 µmol/L (1 mg/dL) uric acid. The genetic score raised uric acid by 17 µmol/L (95%CI: 15,18) per SD increase, and explained 4% of uric acid variation. Using the genetic score to estimate the unconfounded effect found that a 59.48 µmol/L higher uric acid concentration did not have a causal effect on diabetes (HR 1.01, 95%CI: 0.87,1.16). Including data from DIAGRAM consortium, increasing our dataset to 41,508 diabetes cases, the summary OR estimate was 0.99 (95%CI: 0.92, 1.06). In conclusion, our study does not support a causal effect of circulating uric acid on diabetes risk. Uric acid lowering therapies may therefore not be beneficial in reducing diabetes risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- art (subject category)
- ref (subject category)
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Diabetes
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- By the author/editor
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Sluijs, Ivonne
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Holmes, Michael ...
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van der Schouw, ...
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Beulens, Joline ...
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Asselbergs, Folk ...
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Huerta, José Mar ...
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show more...
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Palmer, Tom M
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Arriola, Larrait ...
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Balkau, Beverley
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Barricarte, Aure ...
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Boeing, Heiner
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Clavel-Chapelon, ...
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Fagherazzi, Guy
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Franks, Paul
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Gavrila, Diana
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Kaaks, Rudolf
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Khaw, Kay Tee
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Kühn, Tilman
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Molina-Montes, E ...
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Mortensen, Lotte ...
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Nilsson, Peter
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Overvad, Kim
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Palli, Domenico
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Panico, Salvator ...
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Quirós, J Ramón
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Rolandsson, Olov
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Sacerdote, Carlo ...
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Sala, Núria
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Schmidt, Julie A
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Scott, Robert A
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Sieri, Sabina
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Slimani, Nadia
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Spijkerman, Anne ...
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Tjonneland, Anne
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Travis Dphil, Ru ...
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Tumino, Rosario
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van der A, Daphn ...
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Sharp, Stephen J
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Forouhi, Nita G
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Langenberg, Clau ...
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Riboli, Elio
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Wareham, Nichola ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Diabetes
- By the university
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Lund University
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Umeå University