Sökning: id:"swepub:oai:DiVA.org:kau-83896" >
Persistent organic ...
Persistent organic pollutants in pregnant women potentially affect child development and thyroid hormone status
-
- Krönke, Anna A. (författare)
- University of Leipzig, DEU; Leipzig University Hospital, DEU
-
- Jurkutat, Anne (författare)
- University of Leipzig, DEU
-
- Schlingmann, Maike (författare)
- University Leipzig, DEU
-
visa fler...
-
- Poulain, Tanja (författare)
- University Leipzig, DEU
-
- Nüchter, Matthias (författare)
- University Leipzig, DEU
-
- Hilbert, Anja (författare)
- University Leipzig, DEU
-
- Kiviranta, Hannu (författare)
- Finnish Institute for Health and Welfare, FIN
-
- Körner, Antje (författare)
- University of Leipzig, DEU
-
- Vogel, Mandy (författare)
- University of Leipzig, DEU
-
- Söder, Olle (författare)
- Karolinska Institutet
-
- Bornehag, Carl-Gustaf, 1957- (författare)
- Karlstads universitet,Institutionen för hälsovetenskaper (from 2013),Icahn School of Medicine at Mount Sinai, USA
-
- Kiess, Wieland (författare)
- University of Leipzig, DEU
-
visa färre...
-
(creator_code:org_t)
- 2021-04-06
- 2022
- Engelska.
-
Ingår i: Pediatric Research. - : Springer Nature. - 0031-3998 .- 1530-0447. ; 91:3, s. 690-698
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://kau.diva-por... (primary) (Raw object)
-
https://www.nature.c...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background Potentially harmful effects of persistent organic pollutants (POPs) such as polychlorinated biphenyls (PCBs) and dichlorodiphenyltrichloroethane (DDT) on prenatal development and the endocrine system have been controversially discussed. Methods Working with a German cohort of 324 pregnant women, we assessed POP levels and used robust linear regression models to determine potential associations between maternal POP concentrations and pre- and postnatal development in the children, as well as the thyroid hormone status of the mother and child. Results Maternal p,p '-dichlorodiphenyldichloroethylene (p,p '-DDE) and most measured PCBs positively correlated with postnatal weight gain. We detected no correlation between newborn birth weight and head circumference, respectively, and maternal PCB and p,p '-DDE serum levels, while body length at birth was negatively associated with the maternal serum concentration of PCB 183. Maternal p,p '-DDE and nearly all PCB serum levels showed a negative correlation with maternal free triiodothyronine (FT3). p,p '-DDE and PCB 74 and 118 were negatively associated with maternal thyroid-stimulating hormone levels. In addition, we identified significant associations between maternal POP levels and thyroid hormone parameters of the child. Conclusions These results indicate that POP exposure likely affects different aspects of pre- and postnatal development and impacts the thyroid hormone status of both mother and child. Impact Pregnant women in a German cohort display a substantial accumulation of POPs. Body mass index and age influence maternal serum POP levels. Maternal POP levels show correlations with the child's length at birth and weight gain, and FT3 levels in the mother and child. Our data provide additional evidence for the potentially harmful influence of POPs. Our data indicate that POPs influence pre- and postnatal development.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Public Health Science
- Folkhälsovetenskap
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Krönke, Anna A.
-
Jurkutat, Anne
-
Schlingmann, Mai ...
-
Poulain, Tanja
-
Nüchter, Matthia ...
-
Hilbert, Anja
-
visa fler...
-
Kiviranta, Hannu
-
Körner, Antje
-
Vogel, Mandy
-
Söder, Olle
-
Bornehag, Carl-G ...
-
Kiess, Wieland
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Reproduktionsmed ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Hälsovetenskap
-
och Folkhälsovetensk ...
- Artiklar i publikationen
-
Pediatric Resear ...
- Av lärosätet
-
Karlstads universitet
-
Karolinska Institutet