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Entropy-driven cell...
Entropy-driven cell decision-making predicts ‘fluid-to-solid’ transition in multicellular systems
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- Barua, Arnab (författare)
- Helmholtz Centre for Infection Research, DEU; Center for Information Services and High Performance Computing, DEU
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- Syga, Simon (författare)
- Center for Information Services and High Performance Computing, DEU
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- Mascheroni, Pietro (författare)
- Centre for Infection Research, DEU
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- Kavallaris, Nikos I. (författare)
- University of Chester, GBR
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- Meyer-Hermann, Michael (författare)
- Centre for Infection Research, DEU; Technische Universität Braunschweig, DEU
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- Deutsch, Andreas (författare)
- Center for Information Services and High Performance Computing, DEU
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- Hatzikirou, Haralampos (författare)
- Braunschweig Integrated Centre of Systems Biology, DEU; Center for Information Services and High Performance Computing, DEU; Khalifa University, ARE
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(creator_code:org_t)
- 2020-12-22
- 2020
- Engelska.
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Ingår i: New Journal of Physics. - : Institute of Physics (IOP). - 1367-2630. ; 22:12, s. 123034-123034
- Relaterad länk:
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Cellular decision making allows cells to assume functionally different phenotypes in response to microenvironmental cues, with or without genetic change. It is an open question, how individual cell decisions influence the dynamics at the tissue level. Here, we study spatio-temporal pattern formation in a population of cells exhibiting phenotypic plasticity, which is a paradigm of cell decision making. We focus on the migration/resting and the migration/proliferation plasticity which underly the epithelial-mesenchymal transition and the go or grow dichotomy. We assume that cells change their phenotype in order to minimize their microenvironmental entropy following the LEUP (Least microEnvironmental Uncertainty Principle) hypothesis. In turn, we study the impact of the LEUP-driven migration/resting and migration/proliferation plasticity on the corresponding multicellular spatio-temporal dynamics with a stochastic cell-based mathematical model for the spatio-temporal dynamics of the cell phenotypes. In the case of the go or rest plasticity, a corresponding mean-field approximation allows to identify a bistable switching mechanism between a diffusive (fluid) and an epithelial (solid) tissue phase which depends on the sensitivity of the phenotypes to the environment. For the go or grow plasticity, we show the possibility of Turing pattern formation for the ‘solid’ tissue phase and its relation with the parameters of the LEUP-driven cell decisions.
Ämnesord
- NATURVETENSKAP -- Matematik -- Beräkningsmatematik (hsv//swe)
- NATURAL SCIENCES -- Mathematics -- Computational Mathematics (hsv//eng)
Nyckelord
- Cell-decision making; Fluid-to-solid transition; Langevin equations; Least microEnvironmental uncertainty principle (LEUP); Mean-field theory; Phenotypic plasticity
- Matematik
- Mathematics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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