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Association of per-...
Association of per- and polyfluoroalkyl substances with thyroid homeostasis during pregnancy in the SELMA study
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- Derakhshan, Arash (författare)
- Erasmus University Medical Center, The Netherlands
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- Kortenkamp, Andreas (författare)
- Brunel University, UK,Brunel University London
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- Shu, Huan, 1980- (författare)
- Karlstad University,Karlstads universitet,Institutionen för hälsovetenskaper (from 2013)
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- Broeren, Maarten A.C (författare)
- Máxima Medical Centre, The Netherlands,Maxima Medisch Centrum
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- Lindh, Christian H. (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups
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- Peeters, Robin P. (författare)
- Erasmus University Medical Center, The Netherlands
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- Bornehag, Carl-Gustaf, 1957- (författare)
- Karlstad University,Karlstads universitet,Institutionen för hälsovetenskaper (from 2013),Icahn School of Medicine at Mount Sinai, USA
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- Demeneix, Barbara (författare)
- Muséum National d'Histoire Naturelle, France,National Museum of Natural History
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- Korevaar, Tim I.M. (författare)
- Erasmus University Medical Center, The Netherlands
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(creator_code:org_t)
- Elsevier, 2022
- 2022
- Engelska.
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Ingår i: Environment International. - : Elsevier. - 0160-4120 .- 1873-6750. ; 167
- Relaterad länk:
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https://doi.org/10.1...
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https://kau.diva-por... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- ObjectivesTo investigate the association of exposure to per- and polyfluoroalkyl substances (PFAS) during early pregnancy with markers of the maternal thyroid system.MethodsSerum concentrations of seven PFAS as well as thyroid stimulating hormone (TSH), free and total thyroxine (FT4 and TT4), free and total triiodothyronine (FT3 and TT3) were measured in pregnant women in early pregnancy in the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy (SELMA) study. Outcomes were concentrations of TSH and thyroid hormones, FT4/FT3 or TT4/TT3 ratios, TSH/FT4 ratio as a marker of the negative feedback loop, TT4/FT4 or TT3/FT3 ratios as markers of the binding of thyroid hormones to binding proteins.ResultsThe study population comprised 2,008 women with median (95% range) gestational age of 10 (6–14) weeks. There was no association between PFAS and TSH. Higher PFNA, PFDA, PFHpA and PFOA levels were associated with a higher FT4 (largest effect estimate for PFDA: β [95% CI]: 0.27 [0.10 to 0.45], P = 0.002). Higher PFUnDA levels, but no other PFAS, were associated with a lower FT3 (β [95% CI]: −0.05 [-0.09 to −0.01], P = 0.005). Higher PFUnDA levels were associated with lower TT4 (β [95% CI]: −1.58 [-3.07 to −0.09]) and there was an inverted U-shaped association of PFOS with TT4 (P = 0.03). Higher PFDA, PFUnDA, PFHpA levels were associated with a lower TT3. Overall, higher PFAS concentrations were associated with a higher FT4/FT3 ratio and a higher TT4/TT3 ratio. There was no association of PFAS with the TSH/FT4 ratio. Higher concentrations of several PFAS were associated with lower TT4/FT4 and TT3/FT3 ratios.ConclusionsThese findings translate results from experimental studies suggesting that exposure to PFAS may interfere with the thyroid system during pregnancy. Further experimental studies should take into account human evidence to better understand the potential underlying mechanisms of thyroid disruption by PFAS exposure.
Ämnesord
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
- LANTBRUKSVETENSKAPER -- Lantbruksvetenskap, skogsbruk och fiske -- Livsmedelsvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Agriculture, Forestry and Fisheries -- Food Science (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- Endocrinology; Obstetrics; Physiology; Proteins
- Early pregnancy; Homoeostasis; Negative feedback loop; Polyfluoroalkyl substances; Pregnant woman; Serum concentration; Swedishs; Thyroid hormones; Thyroid stimulating hormones; Thyroid systems
- Hormones
- biomarker; concentration (composition); experimental study; homeostasis; pregnancy; serum
- Environmental Science
- Miljövetenskap
- Biomedical Sciences
- Biomedicinsk vetenskap
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Derakhshan, Aras ...
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Kortenkamp, Andr ...
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Shu, Huan, 1980-
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Broeren, Maarten ...
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Lindh, Christian ...
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Peeters, Robin P ...
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Bornehag, Carl-G ...
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Demeneix, Barbar ...
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Korevaar, Tim I. ...
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Environment Inte ...
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Karlstads universitet
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