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Expectancy effects ...
Expectancy effects on serotonin and dopamine transporters during SSRI treatment of social anxiety disorder : a randomized clinical trial
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- Hjorth, Olof (författare)
- Uppsala universitet,Institutionen för psykologi,Uppsala Univ, Sweden
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- Frick, Andreas, Docent (författare)
- Uppsala universitet,Cervenka: Psykiatri,Institutionen för psykologi,Uppsala Univ, Sweden; Uppsala Univ, Sweden
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- Gingnell, Malin, 1982- (författare)
- Uppsala universitet,Institutionen för psykologi,Cervenka: Psykiatri,Uppsala Univ, Sweden; Uppsala Univ, Sweden
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- Hoppe, Johanna M. (författare)
- Uppsala universitet,Institutionen för psykologi,Uppsala Univ, Sweden
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- Faria, Vanda (författare)
- Uppsala universitet,Institutionen för psykologi,Center for Pain and the Brain, Department of Anesthesiology Perioperative and Pain Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA;Smell & Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany,Uppsala Univ, Sweden; Harvard Med Sch, MA 02115 USA; Tech Univ Dresden, Germany
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- Hultberg, Sara (författare)
- Uppsala universitet,Institutionen för psykologi,Uppsala Univ, Sweden
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- Alaie, Iman (författare)
- Uppsala universitet,Ramklint: Barn- och ungdomspsykiatri,Uppsala Univ, Sweden
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- Mansson, Kristoffer N. T. (författare)
- Karolinska Institutet,Center for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden;Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany;Max Planck UCL Center for Computational Psychiatry and Ageing Research, Berlin/London, UK,Karolinska Inst, Sweden; Max Planck Inst Human Dev, Germany; Max Planck UCL Ctr Computat Psychiat & Ageing Res, England
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- Rosén, Jörgen (författare)
- Uppsala universitet,Institutionen för psykologi,Uppsala Univ, Sweden
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- Reis, Margareta (författare)
- Linköpings universitet,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten,Skane Univ Hosp, Sweden,Department of Biomedical And Clinical Sciences, Linköping University, Linköping, Sweden;Department of Clinical Chemistry and Pharmacology, Skåne University hospital, Lund, Sweden
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- Wahlstedt, Kurt (författare)
- Uppsala universitet,Institutionen för psykologi,Uppsala Univ, Sweden
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- Jonasson, My (författare)
- Uppsala universitet,Radiologi,Uppsala Univ, Sweden
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- Lubberink, Mark (författare)
- Uppsala universitet,Radiologi,Uppsala Univ, Sweden
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- Antoni, Gunnar (författare)
- Uppsala universitet,Preparativ läkemedelskemi,Uppsala Univ, Sweden
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- Fredrikson, Mats (författare)
- Uppsala universitet,Institutionen för psykologi,Uppsala Univ, Sweden; Karolinska Inst, Sweden
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- Furmark, Tomas (författare)
- Uppsala universitet,Institutionen för psykologi,Uppsala Univ, Sweden
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(creator_code:org_t)
- 2021-11-03
- 2021
- Engelska.
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Ingår i: Translational Psychiatry. - : Springer Nature. - 2158-3188. ; 11:1
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://www.nature.c...
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- It has been extensively debated whether selective serotonin reuptake inhibitors (SSRIs) are more efficacious than placebo in affective disorders, and it is not fully understood how SSRIs exert their beneficial effects. Along with serotonin transporter blockade, altered dopamine signaling and psychological factors may contribute. In this randomized clinical trial of participants with social anxiety disorder (SAD) we investigated how manipulation of verbally-induced expectancies, vital for placebo response, affect brain monoamine transporters and symptom improvement during SSRI treatment. Twenty-seven participants with SAD (17 men, 10 women), were randomized, to 9 weeks of overt or covert treatment with escitalopram 20 mg. The overt group received correct treatment information whereas the covert group was treated deceptively with escitalopram, described as an active placebo in a cover story. Before and after treatment, patients underwent positron emission tomography (PET) assessments with the [C-11]DASB and [C-11]PE2I radiotracers, probing brain serotonin (SERT) and dopamine (DAT) transporters. SAD symptoms were measured by the Liebowitz Social Anxiety Scale. Overt was superior to covert SSRI treatment, resulting in almost a fourfold higher rate of responders. PET results showed that SERT occupancy after treatment was unrelated to anxiety reduction and equally high in both groups. In contrast, DAT binding decreased in the right putamen, pallidum, and the left thalamus with overt SSRI treatment, and increased with covert treatment, resulting in significant group differences. DAT binding potential changes in these regions correlated negatively with symptom improvement. Findings support that the anxiolytic effects of SSRIs involve psychological factors contingent on dopaminergic neurotransmission while serotonin transporter blockade alone is insufficient for clinical response.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Hjorth, Olof
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Frick, Andreas, ...
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Gingnell, Malin, ...
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Hoppe, Johanna M ...
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Faria, Vanda
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Hultberg, Sara
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visa fler...
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Alaie, Iman
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Mansson, Kristof ...
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Rosén, Jörgen
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Reis, Margareta
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Wahlstedt, Kurt
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Jonasson, My
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Lubberink, Mark
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Antoni, Gunnar
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Fredrikson, Mats
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Furmark, Tomas
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Psykiatri
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- SAMHÄLLSVETENSKAP
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SAMHÄLLSVETENSKA ...
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och Psykologi
- Artiklar i publikationen
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Translational Ps ...
- Av lärosätet
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Linköpings universitet
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Karolinska Institutet
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Uppsala universitet