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The Relationship of...
The Relationship of Attention-deficit/Hyperactivity Disorder with Post-traumatic Stress Disorder : A Two-Sample Mendelian Randomization and Population-Based Sibling Comparison Study
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- Wendt, Frank R. (författare)
- Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA; Department of Psychiatry, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA; Department of Anthropology, University of Toronto, Toronto, Ontario, Canada
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- Garcia-Argibay, Miguel, 1988- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper
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- Cabrera-Mendoza, Brenda (författare)
- Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA; Department of Psychiatry, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA
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- Valdimarsdóttir, Unnur A. (författare)
- Karolinska Institutet
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- Gelernter, Joel (författare)
- Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA; Department of Psychiatry, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA
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- Stein, Murray B. (författare)
- Department of Psychiatry, UC San Diego School of Medicine, University of California, San Diego, La Jolla, CA, USA; Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, USA; Veterans Affairs San Diego Healthcare System, San Diego, California, USA
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- Nivard, Michel G. (författare)
- Department of Biological Psychology, Faculty of Behaviour and Movement Sciences, VU University, Amsterdam, The Netherlands
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- Maihofer, Adam X. (författare)
- Department of Psychiatry, UC San Diego School of Medicine, University of California, San Diego, La Jolla, CA, USA; Veterans Affairs San Diego Healthcare System, San Diego, California, USA; Center of Excellence for Stress and Mental Health, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA
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- Nievergelt, Caroline M. (författare)
- Department of Psychiatry, UC San Diego School of Medicine, University of California, San Diego, La Jolla, CA, USA; Veterans Affairs San Diego Healthcare System, San Diego, California, USA; Center of Excellence for Stress and Mental Health, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA
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- Larsson, Henrik, 1975- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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- Mattheisen, Manuel (författare)
- Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
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- Polimanti, Renato (författare)
- Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA; Department of Psychiatry, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA
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- Meier, Sandra (författare)
- Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
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Post-Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium, - (bidragsgivare)
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(creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: Biological Psychiatry. - : Elsevier. - 0006-3223 .- 1873-2402. ; 93:4, s. 362-369
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Attention-deficit/hyperactivity disorder (ADHD) and posttraumatic stress disorder (PTSD) are associated but it is unclear if this is a causal relationship or confounding. We used genetic analyses and sibling comparisons to clarify the direction this relationship.Methods: Linkage Disequilibrium Score Regression and two-sample Mendelian randomization (MR) were used to test for genetic correlation (rg) and bidirectional causal effects using European ancestry genome-wide association studies of ADHD (20,183 cases and 35,191 controls) and six PTSD definitions (up to 320,369 individuals). Several additional variables were included in the analysis to verify the independence of the ADHD-PTSD relationship. In a population-based sibling comparison (N=2,082,118 individuals), Cox regression models were fitted to account for time at risk, a range of sociodemographic factors, and unmeasured familial confounders (via sibling comparisons).Results: ADHD and PTSD had consistent rg (rg range, 0.43-0.52; P < .001). ADHD genetic liability was causally linked with increased risk for PTSD (Beta=0.367, 95% confidence interval (CI), 0.186-0.552, P=7.68x10-5). This result was not affected by heterogeneity, horizontal pleiotropy (MR Egger intercept=4.34x10-4, P=0.961), or other phenotypes, and was consistent across PTSD datasets. However, we found no consistent associations between PTSD genetic liability and ADHD risk. Individuals diagnosed with ADHD were at a higher risk for developing PTSD than their undiagnosed sibling (hazard ratio=2.37, 95% CI 1.98-3.53).Conclusions: Our findings add novel evidence supporting the need for early and effective treatment of ADHD as patients with this diagnosis are at significantly higher risk to develop PTSD later in life.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi -- Tillämpad psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology -- Applied Psychology (hsv//eng)
Nyckelord
- ADHD
- PTSD
- Comorbidities
- Genome-wide association study
- Epidemiology
- Causal inference
- Psychiatry
- Psykiatri
- Epidemiologi
- Epidemiology
- Genetik
- Genetics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Wendt, Frank R.
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Garcia-Argibay, ...
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Cabrera-Mendoza, ...
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Valdimarsdóttir, ...
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Gelernter, Joel
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Stein, Murray B.
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Nivard, Michel G ...
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Maihofer, Adam X ...
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Nievergelt, Caro ...
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Larsson, Henrik, ...
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Mattheisen, Manu ...
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Polimanti, Renat ...
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Meier, Sandra
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Post-Traumatic S ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Psykiatri
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- SAMHÄLLSVETENSKAP
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SAMHÄLLSVETENSKA ...
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och Tillämpad psykol ...
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Biological Psych ...
- Av lärosätet
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Örebro universitet
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Karolinska Institutet