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Genetic contributio...
Genetic contributions to the development of ADHD subtypes from childhood to adolescence
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- Larsson, Henrik, 1975- (författare)
- Karolinska Institutet
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- Lichtenstein, Paul (författare)
- Karolinska Institutet
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- Larsson, Jan-Olov (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Lippincott Williams & Wilkins, 2006
- 2006
- Engelska.
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Ingår i: Journal of the American Academy of Child and Adolescent Psychiatry. - : Lippincott Williams & Wilkins. - 0890-8567 .- 1527-5418. ; 45:8, s. 973-981
- Relaterad länk:
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https://urn.kb.se/re...
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visa fler...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- OBJECTIVES: Little is known about how genes influence the development of symptoms included in the DSM-IV subtypes of attention-deficit/hyperactivity disorder (ADHD) from childhood to adolescence. The aim of this study was to examine genetic influences contributing to the development of hyperactive-impulsive symptoms and inattentive symptoms of ADHD from childhood to adolescence.METHOD: The sample included all 1,480 twin pairs born in Sweden between May 1985 and December 1986. Parents responded to mailed questionnaires on three occasions, when the twins were 8 to 9, 13 to 14, and 16 to 17 years old. The authors used dimensional scales of hyperactivity-impulsivity and inattention derived from a checklist of items based on the DSM symptoms of ADHD.RESULTS: Symptoms of hyperactivity-impulsivity declined with increasing age, whereas there was no decline in symptoms of inattention. Persistent genetic influences explain between 45% and 90% of the total genetic variance in hyperactivity-impulsivity and inattention across age. Persistent genetic variance was primarily operating across subtypes, even though persistent subtype-specific influences were also significant.CONCLUSIONS: The finding of persistent cross-subtype (i.e., combined) and persistent subtype-specific genetic influences (i.e., primarily hyperactive-impulsive and primarily inattentive) are in line with a genetic basis for the DSM-IV classification of ADHD subtypes.
Ämnesord
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- attention-deficit/hyperactivity disorder; inattention; hyperactivity; longitudinal study; twin study
- Psykologi
- Psychology
- Pediatrik
- Pediatrics
- Psychiatry
- Psykiatri
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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