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Serotonin and dopam...
Serotonin and dopamine transporter availability in social anxiety disorder after combined treatment with escitalopram and cognitive-behavioral therapy
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- Hjorth, Olof (författare)
- Uppsala University,Uppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden
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- Frick, Andreas, Docent (författare)
- Uppsala University,Uppsala universitet,Institutionen för psykologi,Psykiatri,Department of Psychology, Uppsala University and The Beijer Laboratory, Department of Medical Sciences, Psychiatry, Uppsala University, Uppsala, Sweden
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- Gingnell, Malin, 1982- (författare)
- Uppsala University,Uppsala universitet,Institutionen för psykologi,Psykiatri,Department of Psychology, Uppsala University and Department of Medical Sciences, Psychiatry, Uppsala University, Uppsala, Sweden
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- Engman, Jonas (författare)
- Uppsala University,Uppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden
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- Björkstrand, Johannes (författare)
- Lund University,Lunds universitet,Institutionen för psykologi,Samhällsvetenskapliga institutioner och centrumbildningar,Samhällsvetenskapliga fakulteten,Department of Psychology,Departments of Administrative, Economic and Social Sciences,Faculty of Social Sciences,Department of Psychology, Lund University, Lund, Sweden
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- Faria, Vanda (författare)
- Center for Pain and the Brain, Department of Anesthesiology Perioperative and Pain Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA and Smell & Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany,Dresden University of Technology
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- Alaie, Iman (författare)
- Uppsala University,Uppsala universitet,Karolinska Institutet,Barn- och ungdomspsykiatri,Department of Medical Sciences, Child and Adolescent Psychiatry, Uppsala University, Uppsala, Sweden
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- Carlbring, Per (författare)
- Stockholm University,Stockholms universitet,Klinisk psykologi,Department of Psychology, Stockholm University, Stockholm, Sweden
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- Andersson, Gerhard, Professor, 1966- (författare)
- Linköpings universitet,Linköping University,Karolinska Institutet,Psykologi,Filosofiska fakulteten,Institutionen för biomedicinska och kliniska vetenskaper,Medicinska fakulteten,Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden,Internet, health and clinical psychology research group
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- Jonasson, My (författare)
- Uppsala University,Uppsala universitet,Radiologi,Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden
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- Lubberink, Mark (författare)
- Uppsala University,Uppsala universitet,Radiologi,Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden
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- Antoni, Gunnar (författare)
- Uppsala University,Uppsala universitet,Preparativ läkemedelskemi,Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden
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- Reis, Margareta, 1959- (författare)
- Linköpings universitet,Linköping University,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten
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- Wahlstedt, Kurt (författare)
- Uppsala University,Uppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden
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- Fredrikson, Mats (författare)
- Uppsala University,Karolinska Institutet,Uppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
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- Furmark, Tomas (författare)
- Uppsala University,Uppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden
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(creator_code:org_t)
- 2022-10-07
- 2022
- Engelska.
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Ingår i: Translational Psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 12:1
- Relaterad länk:
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Abstract
Ämnesord
Stäng
- Selective serotonin reuptake inhibitors (SSRIs) and internet-based cognitive behavioral therapy (ICBT) are recommended treatments of social anxiety disorder (SAD), and often combined, but their effects on monoaminergic signaling are not well understood. In this multi-tracer positron emission tomography (PET) study, 24 patients with SAD were randomized to treatment with escitalopram+ICBT or placebo+ICBT under double-blind conditions. Before and after 9 weeks of treatment, patients were examined with positron emission tomography and the radioligands [11C]DASB and [11C]PE2I, probing the serotonin (SERT) and dopamine (DAT) transporter proteins respectively. Both treatment combinations resulted in significant improvement as measured by the Liebowitz Social Anxiety Scale (LSAS). At baseline, SERT-DAT co-expression was high and, in the putamen and thalamus, co-expression showed positive associations with symptom severity. SERT-DAT co-expression was also predictive of treatment success, but predictor-outcome associations differed in direction between the treatments. After treatment, average SERT occupancy in the SSRI + ICBT group was >80%, with positive associations between symptom improvement and occupancy in the nucleus accumbens, putamen and anterior cingulate cortex. Following placebo+ICBT, SERT binding increased in the raphe nuclei. DAT binding increased in both groups in limbic and striatal areas, but relations with symptom improvement differed, being negative for SSRI + ICBT and positive for placebo + ICBT. Thus, serotonin-dopamine transporter co-expression exerts influence on symptom severity and remission rate in the treatment of social anxiety disorder. However, the monoamine transporters are modulated in dissimilar ways when cognitive-behavioral treatment is given concomitantly with either SSRI-medication or pill placebo.
Ämnesord
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi -- Tillämpad psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology -- Applied Psychology (hsv//eng)
Nyckelord
- social anxiety disorder
- SAD
- serotonin
- dopamine
- escitalopram
- cognitive-behavioral therapy
- CBT
- Psychology
- psykologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Hjorth, Olof
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Frick, Andreas, ...
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Gingnell, Malin, ...
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Engman, Jonas
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Björkstrand, Joh ...
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Faria, Vanda
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visa fler...
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Alaie, Iman
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Carlbring, Per
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Andersson, Gerha ...
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Jonasson, My
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Lubberink, Mark
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Antoni, Gunnar
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Reis, Margareta, ...
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Wahlstedt, Kurt
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Fredrikson, Mats
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Furmark, Tomas
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visa färre...
- Om ämnet
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- SAMHÄLLSVETENSKAP
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SAMHÄLLSVETENSKA ...
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och Psykologi
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- SAMHÄLLSVETENSKAP
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SAMHÄLLSVETENSKA ...
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och Psykologi
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och Tillämpad psykol ...
- Artiklar i publikationen
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Translational Ps ...
- Av lärosätet
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Stockholms universitet
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Karolinska Institutet
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Uppsala universitet
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Lunds universitet
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Linköpings universitet