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Odor Identification...
Odor Identification Deficit as a Predictor of Five-Year Global Cognitive Change : Interactive Effects with Age and ApoE-ε4
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- Olofsson, Jonas K. (författare)
- Umeå universitet,Stockholms universitet,Perception och psykofysik,Department of Psychology, Umeå University, Umeå, Sweden; Stockholm Brain Institute, Stockholm, Sweden,Institutionen för psykologi,Department of Psychology, Stockholm University, 10691 Stockholm, Sweden and Stockholm Brain Institute, Stockholm, Sweden
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- Michael, Rönnlund, 1967- (författare)
- Umeå universitet,Institutionen för psykologi,Centre for Population Studies, Umeå University, Umeå, Sweden
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- Nordin, Steven, 1960- (författare)
- Umeå universitet,Institutionen för psykologi,Department of Psychology, San Diego State University, San Diego, CA, USA
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- Nyberg, Lars, 1966- (författare)
- Umeå universitet,Diagnostisk radiologi,Institutionen för integrativ medicinsk biologi (IMB)
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- Nilsson, Lars-Göran (författare)
- Stockholms universitet,Kognitiv psykologi,Stockholm Brain Institute, Stockholm, Sweden,Department of Psychology, Stockholm University, 10691 Stockholm, Sweden
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- Larsson, Maria (författare)
- Stockholms universitet,Perception och psykofysik,Stockholm Brain Institute, Stockholm, Sweden,Department of Psychology, Stockholm University, 10691 Stockholm, Sweden
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(creator_code:org_t)
- 2009-07-25
- 2009
- Engelska.
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Ingår i: Behavior Genetics. - : Springer Netherlands. - 0001-8244 .- 1573-3297. ; 39:5, s. 496-503
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Olfactory impairments are present in common neurodegenerative disorders and predict conversion to dementia in non-demented individuals with cognitive impairment. In cognitively intact elderly, evidence is sparse regarding the role of olfactory deficits in predicting cognitive impairment. The present study investigated predictors of 5-year prospective decline in the Mini-Mental State Examination (MMSE) in a large (n = 501), population-based sample of elderly (65–90 years) individuals. All participants were genotyped for the ApoE gene, assessed for health factors, and were non-demented at the baseline assessment. After partialling out the influences of demographic and health-factors at baseline and dementia at follow-up, poor odor identification ability in combination with older age and the ApoE-ε4 allele predicted larger prospective global cognitive decline. This effect could not be produced by a vocabulary test. In sum, the findings suggest that an olfactory deficit can dissociate between benign and malign global cognitive development in non-demented, very old ε4-carriers, who are at high risk of developing dementia.
Ämnesord
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Nyckelord
- ApoE
- odor identification
- olfaction
- aging
- dementia
- Psychology
- Psykologi
- Psychology
- psykologi
- Psychology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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