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From COPD epidemiol...
From COPD epidemiology to studies of pathophysiological disease mechanisms : challenges with regard to study design and recruitment process
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- Lindberg, Anne (författare)
- Umeå universitet,Medicin,Department of Public Health and Clinical Medicine, Division of Medicine, Umeå University, Umeå
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- Linder, Robert (författare)
- Umeå universitet,Medicin,Department of Public Health and Clinical Medicine, Division of Medicine, Umeå University, Umeå
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- Backman, Helena (författare)
- Umeå universitet,Yrkes- och miljömedicin,Department of Public Health and Clinical Medicine, Division of Occupational and Environmental Medicine, Umeå University, Umeå
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- Eriksson Ström, Jonas (författare)
- Umeå universitet,Medicin,Department of Public Health and Clinical Medicine, Division of Medicine, Umeå University, Umeå
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- Frølich, Andreas (författare)
- Umeå universitet,Medicin,Department of Public Health and Clinical Medicine, Division of Medicine, Umeå University, Umeå
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- Nilsson, Ulf, 1974- (författare)
- Umeå universitet,Medicin,OLIN-studierna,Department of Public Health and Clinical Medicine, Division of Medicine, Umeå University, Umeå
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- Rönmark, Eva (författare)
- Umeå universitet,Yrkes- och miljömedicin,Department of Public Health and Clinical Medicine, Division of Occupational and Environmental Medicine, Umeå University, Umeå
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- Johansson Strandkvist, Viktor (författare)
- Luleå tekniska universitet,Hälsa och rehabilitering
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- Behndig, Annelie F (författare)
- Umeå universitet,Medicin,Department of Public Health and Clinical Medicine, Division of Medicine, Umeå University, Umeå
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- Blomberg, Anders (författare)
- Umeå universitet,Medicin,Department of Public Health and Clinical Medicine, Division of Medicine, Umeå University, Umeå
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(creator_code:org_t)
- 2017-12-17
- 2017
- Engelska.
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Ingår i: European Clinical Respiratory Journal. - : Taylor & Francis. - 2001-8525. ; 4
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://www.tandfonl...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
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- Background: Chronic obstructive pulmonary disease (COPD) is a largely underdiagnosed disease including several phenotypes. In this report, the design of a study intending to evaluate the pathophysiological mechanism in COPD in relation to the specific phenotypes non-rapid and rapid decline in lung function is described together with the recruitment process of the study population derived from a population based study.Method: The OLIN COPD study includes a population-based COPD cohort and referents without COPD identified in 2002–04 (n = 1986), and thereafter followed annually since 2005. Lung function decline was estimated from baseline in 2002–2004 to 2010 (first recruitment phase) or to 2012/2013 (second recruitment phase). Individuals who met the predefined criteria for the following four groups were identified; group A) COPD grade 2–3 with rapid decline in FEV1 and group B) COPD grade 2–3 without rapid decline in FEV1 (≥60 and ≤30 ml/year, respectively), group C) ever-smokers, and group D) non-smokers with normal lung function. Groups A–C included ever-smokers with >10 pack years. The intention was to recruit 15 subjects in each of the groups A-D.Results: From the database groups A–D were identified; group A n = 37, group B n = 29, group C n = 41, and group D n = 55. Fifteen subjects were recruited from groups C and D, while this goal was not reached in the groups A (n = 12) and B (n = 10). The most common reasons for excluding individuals identified as A or B were comorbidities contraindicating bronchoscopy, or inflammatory diseases/immune suppressive medication expected to affect the outcome.Conclusion: The study is expected to generate important results regarding pathophysiological mechanisms associated with rate of decline in lung function among subjects with COPD and the in-detail described recruitment process, including reasons for non-participation, is a strength when interpreting the results in forthcoming studies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Sjukgymnastik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Physiotherapy (hsv//eng)
Nyckelord
- Chronic obstructive pulmonary disease
- disease mechanisms
- lung function decline
- smoking habits
- lungmedicin
- Lung Medicine
- epidemiologi
- Epidemiology
- Physiotherapy
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Lindberg, Anne
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Linder, Robert
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Backman, Helena
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Eriksson Ström, ...
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Frølich, Andreas
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Nilsson, Ulf, 19 ...
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Rönmark, Eva
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Johansson Strand ...
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Behndig, Annelie ...
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Blomberg, Anders
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Lungmedicin och ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Sjukgymnastik
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European Clinica ...
- Av lärosätet
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Umeå universitet
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Luleå tekniska universitet