Sökning: id:"swepub:oai:DiVA.org:uu-157017" >
Three Different App...
Three Different Approaches for the Clarification of the Interactions between Lipoproteins and Chondroitin-6-sulfate
-
- Lipponen, Katriina (författare)
- Univ Helsinki, Dept Chem, Analyt Chem Lab, FIN-00014 Helsinki, Finland.
-
- Stege, Patricia W. (författare)
- Univ Helsinki, Dept Chem, Analyt Chem Lab, FIN-00014 Helsinki, Finland.;Natl Univ San Luis, CONICET, Dept Chem, INQUISAL,Lab Analyt Chem, San Luis, Argentina.
-
- Cilpa, Geraldine (författare)
- Univ Helsinki, Dept Chem, Analyt Chem Lab, FIN-00014 Helsinki, Finland.
-
visa fler...
-
- Samuelsson, Jorgen (författare)
- Karlstads universitet,Avdelningen för kemi och biomedicinsk vetenskap
-
- Fornstedt, Torgny (författare)
- Karlstads universitet,Uppsala universitet,Analytisk kemi,Avdelningen för kemi och biomedicinsk vetenskap,Karlstad Univ, Dept Chem & Biomed Sci, SE-65188 Karlstad, Sweden.;Uppsala Univ, Dept Phys & Analyt Chem, SE-75124 Uppsala, Sweden.
-
- Riekkola, Marja-Liisa (författare)
- Univ Helsinki, Dept Chem, Analyt Chem Lab, FIN-00014 Helsinki, Finland.
-
visa färre...
-
Univ Helsinki, Dept Chem, Analyt Chem Lab, FIN-00014 Helsinki, Finland Univ Helsinki, Dept Chem, Analyt Chem Lab, FIN-00014 Helsinki, Finland.;Natl Univ San Luis, CONICET, Dept Chem, INQUISAL,Lab Analyt Chem, San Luis, Argentina. (creator_code:org_t)
- 2011-06-24
- 2011
- Engelska.
-
Ingår i: Analytical Chemistry. - : American Chemical Society (ACS). - 0003-2700 .- 1520-6882. ; 83:15, s. 6040-6046
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- Two different experimental approaches were used for obtaining a comprehensive view and understanding of the interactions between apolipoprotein B-100 (ApoB-100) of low-density lipoprotein and apolipoprotein E (ApoE) of high-density lipoprotein and chondroitin-6-sulfate (C6S) of arterial proteoglycan. The techniques employed were partial filling affinity capillary electrophoresis (PF-ACE) and continuous flow quartz crystal inicrobalance (QCM). In addition, molecular dynamic (MD) simulations were used to provide a supportive visual insight into the interaction mechanism. A new tool for analysis of QCM-data was utilized, i.e., adsorption energy distribution calculations, which allowed a deeper understanding of the interactions, especially at different temperatures. The PF-ACE technique probed mainly the strong adsorption interactions whereas in the MD calculations short:- and long-range interactions could be distinguished. Although there are differences in the techniques, a pretty good agreement was achieved between the three approaches for the interaction of 19 amino acid peptide of ApoB with C6S giving log affinity constants of 4.66 by QCM, 5.02 by PP-ACE, and 7.39 by MD, and for 15 amino acid peptide of ApoE with C6S 5.34 by QCM, 5.28 by PT-ACE, and 4.60 by MD at physiological temperature 37.0 degrees C.
Ämnesord
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
Nyckelord
- NATURAL SCIENCES
- NATURVETENSKAP
- Kemi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas