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Restrictive spirome...
Restrictive spirometry versus restrictive lung function using the GLI reference values
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- Myrberg, Tomi (författare)
- Umeå universitet,Anestesiologi och intensivvård
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- Lindberg, Anne (författare)
- Umeå universitet,Avdelningen för medicin
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- Eriksson, Berne (författare)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre,Department of Krefting Research Centre, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden; Department of Research and Development, Region Halland, Halmstad, Sweden
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- Hedman, Linnea, 1979- (författare)
- Umeå universitet,Avdelningen för hållbar hälsa
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- Stridsman, Caroline (författare)
- Umeå universitet,Avdelningen för medicin
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- Lundbäck, B. (författare)
- Department of Research and Development, Region Halland, Halmstad, Sweden
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- Rönmark, Eva (författare)
- Umeå universitet,Avdelningen för hållbar hälsa
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- Backman, Helena (författare)
- Umeå universitet,Avdelningen för hållbar hälsa
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(creator_code:org_t)
- 2022-02-28
- 2022
- Engelska.
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Ingår i: Clinical Physiology and Functional Imaging. - : Wiley. - 1475-0961 .- 1475-097X. ; 42:3, s. 181-189
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: Restrictive lung function may indicate various underlying diseases. The aim of this study was to evaluate the accuracy of different restrictive spirometry patterns (RSPs) to identify restrictive lung function (total lung capacity [TLC] < lower limit of normal [LLN]) according to reference values by the Global Lung Function Initiative (GLI) in a wide age-ranged, general population sample. Methods: A general population sample (n = 607, age 23–72 years, smokers 18.8%) with proper dynamic spirometry and TLC measurements, was included. Accuracy of two main categories of RSP to identify TLC < LLN were evaluated: traditional RSPs (definition 1: FVC < 80% of predicted and FEV1/FVC ≥ 0.7 and definition 2: FVC < LLN and FEV1/FVC ≥ LLN) and RSPs defined by Youden's method (definition 3: FVC < 85.5% of predicted and FEV1/FVC ≥ LLN and definition 4: FVC Z-score < −1.0 and FEV1/FVC ≥ LLN). Results: The prevalence of restrictive lung function (TLC < LLN) was 5.3%. The most accurate cut-offs for FVC to identify TLC < LLN were 85.5% for FVC% of predicted, and −1.0 for FVC Z-score. The traditional RSP definitions 1 and 2 had higher specificity (95.0% and 96.9%) but substantially lower sensitivity compared to RSP definitions 3 and 4. Conclusion: Based on the GLI reference values, the RSP definition FVC < LLN and FEV1/FVC ≥ LLN yielded the highest specificity and may appropriately be used to rule out restrictive lung function. The RSP definition with the most favourable trade-off between sensitivity and specificity, FVC < 85.5% of predicted and FEV1/FVC ≥ LLN, may serve as an alternative with higher sensitivity for screening. © 2022 The Authors. Clinical Physiology and Functional Imaging published by John Wiley & Sons Ltd on behalf of Scandinavian Society of Clinical Physiology and Nuclear Medicine.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- epidemiology
- respiratory function tests
- restrictive lung function
- restrictive spirometry pattern
- spirometry
- total lung capacity
- epidemiology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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