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Learning-related co...
Learning-related contraction of gray matter in rodent sensorimotor cortex is associated with adaptive myelination.
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- Mediavilla, Tomás (författare)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)
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- Özalay, Özgun (författare)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)
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- Estévez-Silva, Héctor M. (författare)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)
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- Frias, Barbara (författare)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)
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- Orädd, Greger (författare)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)
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- Sultan, Fahad R. (författare)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)
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- Brozzoli, Claudio (författare)
- IMPACT, Centre de Recherche en Neurosciences de Lyon, Lyon, France; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Solna, Sweden
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- Garzón, Benjamín (författare)
- Karolinska Institutet
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- Lövdén, Martin, 1972 (författare)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology,Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Solna, Sweden; Department of Psychology, University of Gothenburg, Gothenburg, Sweden
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- Marcellino, Daniel J. (författare)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)
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(creator_code:org_t)
- eLife Sciences Publications, 2022
- 2022
- Engelska.
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Ingår i: eLife. - : eLife Sciences Publications. - 2050-084X. ; 11
- Relaterad länk:
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https://doi.org/10.7...
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https://umu.diva-por... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.7...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- From observations in rodents, it has been suggested that the cellular basis of learning-dependent changes, detected using structural MRI, may be increased dendritic spine density, alterations in astrocyte volume, and adaptations within intracortical myelin. Myelin plasticity is crucial for neurological function, and active myelination is required for learning and memory. However, the dynamics of myelin plasticity and how it relates to morphometric-based measurements of structural plasticity remains unknown. We used a motor skill learning paradigm in male mice to evaluate experience-dependent brain plasticity by voxel-based morphometry (VBM) in longitudinal MRI, combined with a cross-sectional immunohistochemical investigation. Whole-brain VBM revealed nonlinear decreases in gray matter volume (GMV) juxtaposed to nonlinear increases in white matter volume (WMV) within GM that were best modeled by an asymptotic time course. Using an atlas-based cortical mask, we found nonlinear changes with learning in primary and secondary motor areas and in somatosensory cortex. Analysis of cross-sectional myelin immunoreactivity in forelimb somatosensory cortex confirmed an increase in myelin immunoreactivity followed by a return towards baseline levels. Further investigations using quantitative confocal microscopy confirmed these changes specifically to the length density of myelinated axons. The absence of significant histological changes in cortical thickness suggests that nonlinear morphometric changes are likely due to changes in intracortical myelin for which morphometric WMV in somatosensory cortex significantly correlated with myelin immunoreactivity. Together, these observations indicate a nonlinear increase of intracortical myelin during learning and support the hypothesis that myelin is a component of structural changes observed by VBM during learning.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Nyckelord
- Male
- Animals
- Mice
- Gray Matter
- pathology
- Cross-Sectional Studies
- Rodentia
- Magnetic Resonance Imaging
- Motor Cortex
- diagnostic imaging
- pathology
- motor skill learning
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
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eLife
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
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Mediavilla, Tomá ...
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Özalay, Özgun
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Estévez-Silva, H ...
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Frias, Barbara
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Orädd, Greger
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Sultan, Fahad R.
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visa fler...
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Brozzoli, Claudi ...
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Garzón, Benjamín
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Lövdén, Martin, ...
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Marcellino, Dani ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
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- SAMHÄLLSVETENSKAP
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SAMHÄLLSVETENSKA ...
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och Psykologi
- Artiklar i publikationen
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eLife
- Av lärosätet
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Göteborgs universitet
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Umeå universitet
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Karolinska Institutet