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Association of Circ...
Association of Circulating Vitamin D With Colorectal Cancer Depends on Vitamin D-Binding Protein Isoforms : A Pooled, Nested, Case-Control Study
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Gibbs, David Corley (author)
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Song, Mingyang (author)
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McCullough, Marjorie L. (author)
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Um, Caroline Y. (author)
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Bostick, Roberd M. (author)
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Wu, Kana (author)
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Flanders, W. Dana (author)
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Giovannucci, Edward (author)
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Jenab, Mazda (author)
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Brustad, Magritt (author)
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Tjonneland, Anne (author)
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Perez-Cornago, Aurora (author)
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Trichopoulou, Antonia (author)
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Tsilidis, Konstantinos K. (author)
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- Hultdin, Johan (author)
- Umeå universitet,Klinisk kemi
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Gurrea, Aurelio Barricarte (author)
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Bueno-de-Mesquita, Bas (author)
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Mahamat-Saleh, Yahya (author)
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Kuehn, Tilman (author)
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Gunter, Marc J. (author)
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Weiderpass, Elisabete (author)
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Fedirko, Veronika (author)
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(creator_code:org_t)
- 2019-10-15
- 2020
- English.
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In: JNCI CANCER SPECTRUM. - : Oxford University Press. - 2515-5091. ; 4:1
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https://umu.diva-por... (primary) (Raw object)
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: Higher circulating 25-hydroxyvitamin-D [25(OH)D] concentrations are consistently inversely associated with colorectal cancer (CRC) risk in observational studies. However, it is unknown whether this association depends on the functional GC-rs4588*A (Thr436Lys) variant encoding the vitamin D-binding protein-2 (DBP2) isoform, which may affect vitamin D status and bioavailability. Methods: We analyzed data from 1710 incident CRC cases and 1649 incidence-density-matched controls nested within three prospective cohorts of mostly Caucasians. Study-specific incidence rate ratios (RRs) for associations of prediagnostic, seasonstandardized 25(OH)D concentrations according to DBP2 isoform with CRC were estimated using multivariable unconditional logistic regression and were pooled using fixed-effects models. All statistical significance tests were two-sided. Results: The odds of having 25(OH)D concentrations less than 50 nmol/L (considered insufficient by the Institute of Medicine) were 43% higher for each DBP2-encoding variant (rs4588*A) inherited (per DBP2 odds ratio [OR] = 1.43, 95% confidence interval [CI] = 1.27 to 1.62, P-trend = 1.2 x 10(-8)). The association of 25(OH)D concentrations with CRC risk differed by DBP2: 25(OH)D concentrations considered sufficient (> 50 nmol/L), relative to deficient (< 30 nmol/L), were associated with a 53% lower CRC risk among individuals with the DBP2 isoform (RR = 0.47, 95% CI = 0.33 to 0.67), but with a non-statistically significant 12% lower risk among individuals without it (RR = 0.88, 95% CI = 0.61 to 1.27) (P-heterogeneity = .01). Conclusions: Our results suggest that the 25(OH)D-CRC association may differ by DBP isoform, and those with a DBP2-encoding genotype linked to vitamin D insufficiency may particularly benefit from adequate 25(OH)D for CRC prevention.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Gibbs, David Cor ...
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Song, Mingyang
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McCullough, Marj ...
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Um, Caroline Y.
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Bostick, Roberd ...
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Wu, Kana
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show more...
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Flanders, W. Dan ...
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Giovannucci, Edw ...
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Jenab, Mazda
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Brustad, Magritt
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Tjonneland, Anne
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Perez-Cornago, A ...
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Trichopoulou, An ...
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Tsilidis, Konsta ...
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Hultdin, Johan
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Gurrea, Aurelio ...
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Bueno-de-Mesquit ...
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Mahamat-Saleh, Y ...
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Kuehn, Tilman
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Gunter, Marc J.
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Weiderpass, Elis ...
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Fedirko, Veronik ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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JNCI CANCER SPEC ...
- By the university
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Umeå University