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Assessment of Lung ...
Assessment of Lung Cancer Risk on the Basis of a Biomarker Panel of Circulating Proteins
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2018-10-11
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American Medical Association (AMA),2018
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-153133
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-153133URI
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https://doi.org/10.1001/jamaoncol.2018.2078DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:139354625URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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En rättelse har publicerats. DOI: 10.1001/jamaoncol.2018.4576.A correction has been published. DOI: 10.1001/jamaoncol.2018.4576.
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Importance There is an urgent need to improve lung cancer risk assessment because current screening criteria miss a large proportion of cases.Objective To investigate whether a lung cancer risk prediction model based on a panel of selected circulating protein biomarkers can outperform a traditional risk prediction model and current US screening criteria.Design, Setting, and Participants Prediagnostic samples from 108 ever-smoking patients with lung cancer diagnosed within 1 year after blood collection and samples from 216 smoking-matched controls from the Carotene and Retinol Efficacy Trial (CARET) cohort were used to develop a biomarker risk score based on 4 proteins (cancer antigen 125 [CA125], carcinoembryonic antigen [CEA], cytokeratin-19 fragment [CYFRA 21-1], and the precursor form of surfactant protein B [Pro-SFTPB]). The biomarker score was subsequently validated blindly using absolute risk estimates among 63 ever-smoking patients with lung cancer diagnosed within 1 year after blood collection and 90 matched controls from 2 large European population-based cohorts, the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Northern Sweden Health and Disease Study (NSHDS).Main Outcomes and Measures Model validity in discriminating between future lung cancer cases and controls. Discrimination estimates were weighted to reflect the background populations of EPIC and NSHDS validation studies (area under the receiver-operating characteristics curve [AUC], sensitivity, and specificity).Results In the validation study of 63 ever-smoking patients with lung cancer and 90 matched controls (mean [SD] age, 57.7 [8.7] years; 68.6% men) from EPIC and NSHDS, an integrated risk prediction model that combined smoking exposure with the biomarker score yielded an AUC of 0.83 (95% CI, 0.76-0.90) compared with 0.73 (95% CI, 0.64-0.82) for a model based on smoking exposure alone (P = .003 for difference in AUC). At an overall specificity of 0.83, based on the US Preventive Services Task Force screening criteria, the sensitivity of the integrated risk prediction (biomarker) model was 0.63 compared with 0.43 for the smoking model. Conversely, at an overall sensitivity of 0.42, based on the US Preventive Services Task Force screening criteria, the integrated risk prediction model yielded a specificity of 0.95 compared with 0.86 for the smoking model.Conclusions and Relevance This study provided a proof of principle in showing that a panel of circulating protein biomarkers may improve lung cancer risk assessment and may be used to define eligibility for computed tomography screening.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Sun, Nan
(author)
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Bantis, Leonidas E.
(author)
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Muller, David C.
(author)
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Li, Peng
(author)
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Taguchi, Ayumu
(author)
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Dhillon, Dilsher
(author)
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Kundnani, Deepali L.
(author)
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Patel, Nikul J.
(author)
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Yan, Qingxiang
(author)
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Byrnes, Graham
(author)
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Moons, Karel G. M.
(author)
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Tjonneland, Anne
(author)
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Panico, Salvatore
(author)
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Agnoli, Claudia
(author)
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Vineis, Paolo
(author)
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Palli, Domenico
(author)
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Bueno-de-Mesquita, Bas
(author)
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Peeters, Petra H.
(author)
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Agudo, Antonio
(author)
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Huerta, Jose M.
(author)
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Dorronsoro, Miren
(author)
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Rodriguez Barranco, Miguel
(author)
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Ardanaz, Eva
(author)
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Travis, Ruth C.
(author)
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Byme, Karl Smith
(author)
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Boeing, Heiner
(author)
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Steffen, Annika
(author)
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Kaaks, Rudolf
(author)
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Huesing, Anika
(author)
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Trichopoulou, Antonia
(author)
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Lagiou, Pagona
(author)
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La Vecchia, Carlo
(author)
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Severi, Gianluca
(author)
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Boutron-Ruault, Marie-Christine
(author)
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Sandanger, Torkjel M.
(author)
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Weiderpass, ElisabeteKarolinska Institutet
(author)
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Nost, Therese H.
(author)
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Tsilidis, Kostas
(author)
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Riboli, Elio
(author)
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Grankvist, KjellUmeå universitet,Klinisk kemi(Swepub:umu)kjgr0002
(author)
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Johansson, MikaelUmeå universitet,Onkologi(Swepub:umu)mijo0025
(author)
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Goodman, Gary E.
(author)
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Feng, Ziding
(author)
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Brennan, Paul
(author)
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Johansson, Mattias
(author)
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Hanash, Samir M.
(author)
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Karolinska InstitutetKlinisk kemi
(creator_code:org_t)
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In:JAMA Oncology: American Medical Association (AMA)4:102374-24372374-2445
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Sun, Nan
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Muller, David C.
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Li, Peng
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Huerta, Jose M.
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Dorronsoro, Mire ...
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Travis, Ruth C.
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Boeing, Heiner
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Kaaks, Rudolf
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Huesing, Anika
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- MEDICAL AND HEALTH SCIENCES
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JAMA Oncology
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Umeå University
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Karolinska Institutet