Search: onr:"swepub:oai:DiVA.org:umu-42266" >
A multi-stage genom...
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
-
Rothman, Nathaniel (author)
-
Garcia-Closas, Montserrat (author)
-
Chatterjee, Nilanjan (author)
-
show more...
-
Malats, Nuria (author)
-
Wu, Xifeng (author)
-
Figueroa, Jonine D (author)
-
Real, Francisco X (author)
-
Van Den Berg, David (author)
-
Matullo, Giuseppe (author)
-
Baris, Dalsu (author)
-
Thun, Michael (author)
-
Kiemeney, Lambertus A (author)
-
Vineis, Paolo (author)
-
De Vivo, Immaculata (author)
-
Albanes, Demetrius (author)
-
Purdue, Mark P (author)
-
Rafnar, Thorunn (author)
-
Hildebrandt, Michelle A T (author)
-
Kiltie, Anne E (author)
-
Cussenot, Olivier (author)
-
Golka, Klaus (author)
-
Kumar, Rajiv (author)
-
Taylor, Jack A (author)
-
Mayordomo, Jose I (author)
-
Jacobs, Kevin B (author)
-
Kogevinas, Manolis (author)
-
Hutchinson, Amy (author)
-
Wang, Zhaoming (author)
-
Fu, Yi-Ping (author)
-
Prokunina-Olsson, Ludmila (author)
-
Burdett, Laurie (author)
-
Yeager, Meredith (author)
-
Wheeler, William (author)
-
Tardón, Adonina (author)
-
Serra, Consol (author)
-
Carrato, Alfredo (author)
-
García-Closas, Reina (author)
-
Lloreta, Josep (author)
-
Johnson, Alison (author)
-
Schwenn, Molly (author)
-
Karagas, Margaret R (author)
-
Schned, Alan (author)
-
Andriole, Gerald (author)
-
Grubb, Robert (author)
-
Black, Amanda (author)
-
Jacobs, Eric J (author)
-
Diver, W Ryan (author)
-
Gapstur, Susan M (author)
-
Weinstein, Stephanie J (author)
-
Virtamo, Jarmo (author)
-
Cortessis, Victoria K (author)
-
Gago-Dominguez, Manuela (author)
-
Pike, Malcolm C (author)
-
Stern, Mariana C (author)
-
Yuan, Jian-Min (author)
-
Hunter, David J (author)
-
McGrath, Monica (author)
-
Dinney, Colin P (author)
-
Czerniak, Bogdan (author)
-
Chen, Meng (author)
-
Yang, Hushan (author)
-
Vermeulen, Sita H (author)
-
Aben, Katja K (author)
-
Witjes, J Alfred (author)
-
Makkinje, Remco R (author)
-
Sulem, Patrick (author)
-
Besenbacher, Soren (author)
-
Stefansson, Kari (author)
-
Riboli, Elio (author)
-
Brennan, Paul (author)
-
Panico, Salvatore (author)
-
Navarro, Carmen (author)
-
Allen, Naomi E (author)
-
Bueno-de-Mesquita, H Bas (author)
-
Trichopoulos, Dimitrios (author)
-
Caporaso, Neil (author)
-
Landi, Maria Teresa (author)
-
Canzian, Federico (author)
-
- Ljungberg, Börje (author)
- Umeå universitet,Urologi och andrologi
-
Tjonneland, Anne (author)
-
Clavel-Chapelon, Francoise (author)
-
Bishop, David T (author)
-
Teo, Mark T W (author)
-
Knowles, Margaret A (author)
-
Guarrera, Simonetta (author)
-
Polidoro, Silvia (author)
-
Ricceri, Fulvio (author)
-
Sacerdote, Carlotta (author)
-
Allione, Alessandra (author)
-
Cancel-Tassin, Geraldine (author)
-
Selinski, Silvia (author)
-
Hengstler, Jan G (author)
-
Dietrich, Holger (author)
-
Fletcher, Tony (author)
-
Rudnai, Peter (author)
-
Gurzau, Eugen (author)
-
Koppova, Kvetoslava (author)
-
Bolick, Sophia C E (author)
-
Godfrey, Ashley (author)
-
Xu, Zongli (author)
-
Sanz-Velez, José I (author)
-
D García-Prats, María (author)
-
Sanchez, Manuel (author)
-
Valdivia, Gabriel (author)
-
Porru, Stefano (author)
-
Benhamou, Simone (author)
-
Hoover, Robert N (author)
-
Fraumeni, Joseph F (author)
-
Silverman, Debra T (author)
-
Chanock, Stephen J (author)
-
show less...
-
(creator_code:org_t)
- 2010-10-24
- 2010
- English.
-
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 978-984
- Related links:
-
https://europepmc.or...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- confers susceptibility; udp-glucuronosyltransferases; recombination hotspots; telomerase mutations; pulmonary-fibrosis; sequence variant; common variants; chromosome 8q24; down-regulation; cell-carcinoma
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Rothman, Nathani ...
-
Garcia-Closas, M ...
-
Chatterjee, Nila ...
-
Malats, Nuria
-
Wu, Xifeng
-
Figueroa, Jonine ...
-
show more...
-
Real, Francisco ...
-
Van Den Berg, Da ...
-
Matullo, Giusepp ...
-
Baris, Dalsu
-
Thun, Michael
-
Kiemeney, Lamber ...
-
Vineis, Paolo
-
De Vivo, Immacul ...
-
Albanes, Demetri ...
-
Purdue, Mark P
-
Rafnar, Thorunn
-
Hildebrandt, Mic ...
-
Kiltie, Anne E
-
Cussenot, Olivie ...
-
Golka, Klaus
-
Kumar, Rajiv
-
Taylor, Jack A
-
Mayordomo, Jose ...
-
Jacobs, Kevin B
-
Kogevinas, Manol ...
-
Hutchinson, Amy
-
Wang, Zhaoming
-
Fu, Yi-Ping
-
Prokunina-Olsson ...
-
Burdett, Laurie
-
Yeager, Meredith
-
Wheeler, William
-
Tardón, Adonina
-
Serra, Consol
-
Carrato, Alfredo
-
García-Closas, R ...
-
Lloreta, Josep
-
Johnson, Alison
-
Schwenn, Molly
-
Karagas, Margare ...
-
Schned, Alan
-
Andriole, Gerald
-
Grubb, Robert
-
Black, Amanda
-
Jacobs, Eric J
-
Diver, W Ryan
-
Gapstur, Susan M
-
Weinstein, Steph ...
-
Virtamo, Jarmo
-
Cortessis, Victo ...
-
Gago-Dominguez, ...
-
Pike, Malcolm C
-
Stern, Mariana C
-
Yuan, Jian-Min
-
Hunter, David J
-
McGrath, Monica
-
Dinney, Colin P
-
Czerniak, Bogdan
-
Chen, Meng
-
Yang, Hushan
-
Vermeulen, Sita ...
-
Aben, Katja K
-
Witjes, J Alfred
-
Makkinje, Remco ...
-
Sulem, Patrick
-
Besenbacher, Sor ...
-
Stefansson, Kari
-
Riboli, Elio
-
Brennan, Paul
-
Panico, Salvator ...
-
Navarro, Carmen
-
Allen, Naomi E
-
Bueno-de-Mesquit ...
-
Trichopoulos, Di ...
-
Caporaso, Neil
-
Landi, Maria Ter ...
-
Canzian, Federic ...
-
Ljungberg, Börje
-
Tjonneland, Anne
-
Clavel-Chapelon, ...
-
Bishop, David T
-
Teo, Mark T W
-
Knowles, Margare ...
-
Guarrera, Simone ...
-
Polidoro, Silvia
-
Ricceri, Fulvio
-
Sacerdote, Carlo ...
-
Allione, Alessan ...
-
Cancel-Tassin, G ...
-
Selinski, Silvia
-
Hengstler, Jan G
-
Dietrich, Holger
-
Fletcher, Tony
-
Rudnai, Peter
-
Gurzau, Eugen
-
Koppova, Kvetosl ...
-
Bolick, Sophia C ...
-
Godfrey, Ashley
-
Xu, Zongli
-
Sanz-Velez, José ...
-
D García-Prats, ...
-
Sanchez, Manuel
-
Valdivia, Gabrie ...
-
Porru, Stefano
-
Benhamou, Simone
-
Hoover, Robert N
-
Fraumeni, Joseph ...
-
Silverman, Debra ...
-
Chanock, Stephen ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Medical Genetics
- Articles in the publication
-
Nature Genetics
- By the university
-
Umeå University