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Plasma cotinine lev...
Plasma cotinine levels and pancreatic cancer in the EPIC cohort study
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Leenders, Max (author)
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Chuang, Shu-Chun (author)
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Dahm, Christina C. (author)
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Overvad, Kim (author)
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Ueland, Per Magne (author)
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Midttun, Oivind (author)
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Vollset, Stein Emil (author)
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Tjonneland, Anne (author)
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Halkjaer, Jytte (author)
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Jenab, Mazda (author)
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Clavel-Chapelon, Francoise (author)
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Boutron-Ruault, Marie-Christine (author)
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Kaaks, Rudolf (author)
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Canzian, Federico (author)
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Boeing, Heiner (author)
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Weikert, Cornelia (author)
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Trichopoulou, Antonia (author)
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Bamia, Christina (author)
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Naska, Androniki (author)
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Palli, Domenico (author)
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Pala, Valeria (author)
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Mattiello, Amalia (author)
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Tumino, Rosario (author)
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Sacerdote, Carlotta (author)
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van Duijnhoven, Franzel J. B. (author)
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Peeters, Petra H. M. (author)
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van Gils, Carla H. (author)
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Lund, Eiliv (author)
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Rodriguez, Laudina (author)
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Duell, Eric J. (author)
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Sanchez Perez, Maria-Jose (author)
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Molina-Montes, Esther (author)
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Huerta Castano, Jose Maria (author)
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Barricarte, Aurelio (author)
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Larranaga, Nerea (author)
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- Johansen, Dorthe (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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Lindkvist, Bjorn (author)
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- Sund, Malin, 1972- (author)
- Umeå universitet,Kirurgi,Malin Sund
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- Ye, Weimin (author)
- Karolinska Institutet
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Khaw, Kay-Tee (author)
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Wareham, Nicholas J. (author)
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Michaud, Dominique S. (author)
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Riboli, Elio (author)
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Xun, Wei W. (author)
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Allen, Naomi E. (author)
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Crowe, Francesca L. (author)
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Bueno-de-Mesquita, H. Bas (author)
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Vineis, Paolo (author)
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(creator_code:org_t)
- 2011-11-02
- 2012
- English.
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In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 131:4, s. 997-1002
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Abstract
Subject headings
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- Smoking is an established risk factor for pancreatic cancer, previously investigated by the means of questionnaires. Using cotinine as a biomarker for tobacco exposure allows more accurate quantitative analyses to be performed. This study on pancreatic cancer, nested within the European Prospective Investigation into Cancer and Nutrition (EPIC cohort), included 146 cases and 146 matched controls. Using liquid chromatography-mass spectrometry, plasma cotinine levels were analyzed on average 8.0 years before cancer onset (595% range: 2.812.0 years). The relation between plasma cotinine levels and pancreatic cancer was analyzed with conditional logistic regression for different levels of cotinine in a population of never and current smokers. This was also done for the self-reported number of smoked cigarettes per day at baseline. Every increase of 350 nmol/L of plasma cotinine was found to significantly elevate risk of pancreatic cancer [odds ratio (OR): 1.33, 95% confidence interval (CI): 1.111.60]. People with a cotinine level over 1187.8 nmol/L, a level comparable to smoking 17 cigarettes per day, have an elevated risk of pancreatic cancer, compared to people with cotinine levels below 55 nmol/L (OR: 3.66, 95% CI: 1.449.26). The results for self-reported smoking at baseline also show an increased risk of pancreatic cancer from cigarette smoking based on questionnaire information. People who smoke more than 30 cigarettes per day showed the highest risk compared to never smokers (OR: 4.15, 95% CI: 1.0216.42). This study is the first to show that plasma cotinine levels are strongly related to pancreatic cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- EPIC
- smoking
- cotinine
- pancreatic cancer
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Leenders, Max
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Chuang, Shu-Chun
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Dahm, Christina ...
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Overvad, Kim
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Ueland, Per Magn ...
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Midttun, Oivind
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show more...
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Vollset, Stein E ...
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Tjonneland, Anne
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Halkjaer, Jytte
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Jenab, Mazda
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Clavel-Chapelon, ...
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Boutron-Ruault, ...
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Kaaks, Rudolf
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Canzian, Federic ...
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Boeing, Heiner
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Weikert, Corneli ...
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Trichopoulou, An ...
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Bamia, Christina
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Naska, Androniki
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Palli, Domenico
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Pala, Valeria
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Mattiello, Amali ...
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Tumino, Rosario
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Sacerdote, Carlo ...
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van Duijnhoven, ...
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Peeters, Petra H ...
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van Gils, Carla ...
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Lund, Eiliv
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Rodriguez, Laudi ...
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Duell, Eric J.
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Sanchez Perez, M ...
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Molina-Montes, E ...
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Huerta Castano, ...
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Barricarte, Aure ...
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Larranaga, Nerea
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Johansen, Dorthe
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Lindkvist, Bjorn
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Sund, Malin, 197 ...
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Ye, Weimin
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Khaw, Kay-Tee
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Wareham, Nichola ...
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Michaud, Dominiq ...
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Riboli, Elio
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Xun, Wei W.
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Allen, Naomi E.
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Crowe, Francesca ...
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Bueno-de-Mesquit ...
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Vineis, Paolo
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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International Jo ...
- By the university
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Lund University
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Umeå University
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Karolinska Institutet