Interaction of Dietary and Genetic Factors Influencing Body Iron Status and Risk of Type 2 Diabetes Within the EPIC-InterAct Study

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Interaction of Dietary and Genetic Factors Influencing Body Iron Status and Risk of Type 2 Diabetes Within the EPIC-InterAct Study

Meidtner, Karina (författare): German Institute of Human Nutrition,German Center for Diabetes Research

Podmore, Clara (författare): University of Cambridge

Kroger, Janine (författare): German Institute of Human Nutrition

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van der Schouw, Yvonne T. (författare): University Medical Center Utrecht

Bendinelli, Benedetta (författare): Cancer Research and Prevention Institute (ISPO),German Center for Diabetes Research,German Institute of Human Nutrition

Agnoli, Claudia (författare): Istituto Nazionale dei Tumori

Arriola, Larraitz (författare): Biodonostia Health Research Institute,Public Health Division of Gipuzkoa,CIBER Epidemiology and Public Health (CIBERESP)

Barricarte, Aurelio (författare): Navarre Public Health Institute (ISPN),CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)

Boeing, Heiner (författare): German Institute of Human Nutrition

Cross, Amanda J. (författare): Imperial College London,International Agency for Research on Cancer, World Health Organization

Dow, Courtney (författare): Centre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay,Institut Gustave Roussy

Ekblom, Kim (författare): Umeå University,Umeå universitet,Klinisk kemi

Fagherazzi, Guy (författare): Institut Gustave Roussy,University of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP)

Franks, Paul W. (författare): Umeå University,Umeå universitet,Avdelningen för medicin,Department of Clinical Sciences, Lund University, Malmö, Sweden

Gunter, Marc J. (författare): International Agency for Research on Cancer, World Health Organization

Huerta, Jose Maria (författare): Biodonostia Health Research Institute,Murcia Regional Health Council

Jakszyn, Paula (författare): Ramon Llull University,Catalan Institute of Oncology

Jenab, Mazda (författare)

Katzke, Verena A. (författare): German Cancer Research Centre

Key, Timothy J. (författare): University of Oxford

Khaw, Kay Tee (författare): University of Cambridge

Kuhn, Tilman (författare): German Cancer Research Centre

Kyro, Cecilie (författare): Danish Cancer Society

Mancini, Francesca Romana (författare): Institut Gustave Roussy,University of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP)

Melander, Olle (författare): Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups

Nilsson, Peter M. (författare): Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups

Overvad, Kim (författare): Aarhus University,Aalborg University

Palli, Domenico (författare): Cancer Research and Prevention Institute (ISPO)

Panico, Salvatore (författare): University of Naples Federico II

Quiros, J. Ramon (författare): Public Health Directorate

Rodriguez-Barranco, Miguel (författare): CIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP)

Sacerdote, Carlotta (författare): Citta' della Salute e della Scienza Hospital-University of Turin,Human Genetics Foundation (HuGeF)

Sluijs, Ivonne (författare): University Medical Center Utrecht

Stepien, Magdalena (författare): International Agency for Research on Cancer, World Health Organization

Tjonneland, Anne (författare): Danish Cancer Society

Tumino, Rosario (författare): L’ Associazione Iblea per la Ricerca Epidemiologica (A.I.R.E.),Civic and M.P Arezzo Hospital

Forouhi, Nita G. (författare): University of Cambridge

Sharp, Stephen J. (författare): University of Cambridge

Langenberg, Claudia (författare): University of Cambridge

Schulze, Matthias B. (författare)

Riboli, Elio (författare): Imperial College London

Wareham, Nicholas J. (författare): University of Cambridge

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(creator_code:org_t)

2017-11-22
2018
Engelska.
Ingår i: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 41:2, s. 277-285

Relaterad länk:: https://care.diabete...; visa fler...; http://dx.doi.org/10...; https://urn.kb.se/re...; https://doi.org/10.2...; https://lup.lub.lu.s...; visa färre...

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OBJECTIVE: Meat intake has been consistently shown to be positively associated with incident type 2 diabetes. Part of that association may be mediated by body iron status, which is influenced by genetic factors. We aimed to test for interactions of genetic and dietary factors influencing body iron status in relation to the risk of incident type 2 diabetes.RESEARCH DESIGN AND METHODS: The case-cohort comprised 9,347 case subjects and 12,301 subcohort participants from eight European countries. Single nucleotide polymorphisms (SNPs) were selected from genome-wide association studies on iron status biomarkers and candidate gene studies. A ferritin-related gene score was constructed. Multiplicative and additive interactions of heme iron and SNPs as well as the gene score were evaluated using Cox proportional hazards regression.RESULTS: Higher heme iron intake (per 1 SD) was associated with higher ferritin levels (β = 0.113 [95% CI 0.082; 0.144]), but not with transferrin (−0.019 [−0.043; 0.006]) or transferrin saturation (0.016 [−0.006; 0.037]). Five SNPs located in four genes (rs1799945 [HFE H63D], rs1800562 [HFE C282Y], rs236918 [PCK7], rs744653 [SLC40A1], and rs855791 [TMPRSS6V736A]) were associated with ferritin. We did not detect an interaction of heme iron and the gene score on the risk of diabetes in the overall study population (Padd = 0.16, Pmult = 0.21) but did detect a trend toward a negative interaction in men (Padd = 0.04, Pmult = 0.03).CONCLUSIONS: We found no convincing evidence that the interplay of dietary and genetic factors related to body iron status associates with type 2 diabetes risk above the level expected from the sum or product of the two individual exposures.

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Av författaren/redakt...: Meidtner, Karina; Podmore, Clara; Kroger, Janine; van der Schouw, ...; Bendinelli, Bene ...; Agnoli, Claudia; visa fler...; Arriola, Larrait ...; Barricarte, Aure ...; Boeing, Heiner; Cross, Amanda J.; Dow, Courtney; Ekblom, Kim; Fagherazzi, Guy; Franks, Paul W.; Gunter, Marc J.; Huerta, Jose Mar ...; Jakszyn, Paula; Jenab, Mazda; Katzke, Verena A ...; Key, Timothy J.; Khaw, Kay Tee; Kuhn, Tilman; Kyro, Cecilie; Mancini, Frances ...; Melander, Olle; Nilsson, Peter M ...; Overvad, Kim; Palli, Domenico; Panico, Salvator ...; Quiros, J. Ramon; Rodriguez-Barran ...; Sacerdote, Carlo ...; Sluijs, Ivonne; Stepien, Magdale ...; Tjonneland, Anne; Tumino, Rosario; Forouhi, Nita G.; Sharp, Stephen J ...; Langenberg, Clau ...; Schulze, Matthia ...; Riboli, Elio; Wareham, Nichola ...; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Endokrinologi oc ...

Artiklar i publikationen: Diabetes Care

Av lärosätet: Umeå universitet; Lunds universitet

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Interaction of Dietary and Genetic Factors Influencing Body Iron Status and Risk of Type 2 Diabetes Within the EPIC-InterAct Study

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