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From cohorts to mol...
From cohorts to molecules: Adverse impacts of endocrine disrupting mixtures
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- Caporale, N. (författare)
- High Definition Disease Modelling Lab, Stem Cell and Organoid Epigenetics, IEO, European Institute of Oncology, IRCCS, Milan, Italy; Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy; Human Technopole, V.le Rita Levi-Montalcini, Milan, Italy,European Inst Oncol, High Definit Dis Modelling Lab, IRCCS, IEO,Stem Cell & Organoid Epigenet, I-20141 Milan, Italy.;Univ Milan, Dept Oncol & Hematooncol, I-20122 Milan, Italy.;Human Technopole, Vle Rita Levi Montalcini 1, I-20157 Milan, Italy.
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- Leemans, M. (författare)
- UMR 7221, Phyma, CNRS-Muséum National d'Histoire Naturelle, Sorbonne Université, Paris, France,Sorbonne University, FRA; University Paris, FRA,Sorbonne Univ, CNRS Museum Natl dHist Nat, Phyma, UMR 7221, F-75005 Paris, France.;Univ Paris Est Creteil, Team CEpiA, IMRB, INSERM, F-94010 Crete, France.
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- Birgersson, Lina, 1989 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biologi och miljövetenskap,Department of Biological and Environmental Sciences,Department of Biological and Environmental Sciences, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Dept Biol & Environm Sci, S-41463 Gothenburg, Sweden.
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visa fler...
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- Germain, P. L. (författare)
- High Definition Disease Modelling Lab, Stem Cell and Organoid Epigenetics, IEO, European Institute of Oncology, IRCCS, Milan, Italy,European Institute of Oncology, ITA; Swiss Federal Institute of Technology, CHE;University of Zurich, CHE,European Inst Oncol, High Definit Dis Modelling Lab, IRCCS, IEO,Stem Cell & Organoid Epigenet, I-20141 Milan, Italy.;Swiss Fed Inst Technol, D HEST Inst Neurosci, Zurich, Switzerland.;Univ Zurich, Lab Stat Bioinformat, Zurich, Switzerland.
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- Cheroni, C. (författare)
- High Definition Disease Modelling Lab, Stem Cell and Organoid Epigenetics, IEO, European Institute of Oncology, IRCCS, Milan, Italy; Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy; Human Technopole, V.le Rita Levi-Montalcini, Milan, Italy,European Inst Oncol, High Definit Dis Modelling Lab, IRCCS, IEO,Stem Cell & Organoid Epigenet, I-20141 Milan, Italy.;Univ Milan, Dept Oncol & Hematooncol, I-20122 Milan, Italy.;Human Technopole, Vle Rita Levi Montalcini 1, I-20157 Milan, Italy.
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- Borbély, G. (författare)
- Swedish Toxicology Sciences Research Center (SWETOX), Södertälje, Sweden,Swedish Toxicol Sci Res Ctr SWETOX, Södertälje, Sweden.
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- Engdahl, Elin (författare)
- Uppsala universitet,Uppsala University,Miljötoxikologi,Swedish Toxicol Sci Res Ctr SWETOX, Södertälje, Sweden
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- Lindh, Christian (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Lund Univ, Dept Lab Med, Div Occupat & Environm Med, SE-22185 Lund, Sweden.
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- Bressan, R. B. (författare)
- Medical Research Council Centre for Regenerative Medicine and Edinburgh Cancer Research UK Centre, University of Edinburgh, Edinburgh, UK,Univ Edinburgh, Med Res Council Ctr Regenerat Med & Edinburgh Can, Edinburgh, Midlothian, Scotland.
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- Cavallo, F. (författare)
- High Definition Disease Modelling Lab, Stem Cell and Organoid Epigenetics, IEO, European Institute of Oncology, IRCCS, Milan, Italy,European Institute of Oncology, ITA.;University of Milan, ITA,European Inst Oncol, High Definit Dis Modelling Lab, IRCCS, IEO,Stem Cell & Organoid Epigenet, I-20141 Milan, Italy.
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- Nånberg, Eewa, 1957- (författare)
- Örebro universitet,Institutionen för hälsovetenskaper,Örebro University, Sweden,Örebro Univ, Sch Hlth Sci, SE-70182 Örebro, Sweden.
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- D’Agostino, G. A. (författare)
- High Definition Disease Modelling Lab, Stem Cell and Organoid Epigenetics, IEO, European Institute of Oncology, IRCCS, Milan, Italy,European Institute of Oncology, ITA.;University of Milan, ITA;Nanyang Technology University, SGP,European Inst Oncol, High Definit Dis Modelling Lab, IRCCS, IEO,Stem Cell & Organoid Epigenet, I-20141 Milan, Italy.;Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore.
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- Pollard, S. M. (författare)
- Medical Research Council Centre for Regenerative Medicine and Edinburgh Cancer Research UK Centre, University of Edinburgh, Edinburgh, UK,Univ Edinburgh, Med Res Council Ctr Regenerat Med & Edinburgh Can, Edinburgh, Midlothian, Scotland.
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- Rigoli, M. T. (författare)
- High Definition Disease Modelling Lab, Stem Cell and Organoid Epigenetics, IEO, European Institute of Oncology, IRCCS, Milan, Italy; Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy,European Inst Oncol, High Definit Dis Modelling Lab, IRCCS, IEO,Stem Cell & Organoid Epigenet, I-20141 Milan, Italy.;Univ Milan, Dept Oncol & Hematooncol, I-20122 Milan, Italy.
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- Tenderini, E. (författare)
- High Definition Disease Modelling Lab, Stem Cell and Organoid Epigenetics, IEO, European Institute of Oncology, IRCCS, Milan, Italy,European Inst Oncol, High Definit Dis Modelling Lab, IRCCS, IEO,Stem Cell & Organoid Epigenet, I-20141 Milan, Italy.
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- Tobon, A. L. (författare)
- High Definition Disease Modelling Lab, Stem Cell and Organoid Epigenetics, IEO, European Institute of Oncology, IRCCS, Milan, Italy,European Inst Oncol, High Definit Dis Modelling Lab, IRCCS, IEO,Stem Cell & Organoid Epigenet, I-20141 Milan, Italy.
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- Trattaro, S. (författare)
- High Definition Disease Modelling Lab, Stem Cell and Organoid Epigenetics, IEO, European Institute of Oncology, IRCCS, Milan, Italy; Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy,European Inst Oncol, High Definit Dis Modelling Lab, IRCCS, IEO,Stem Cell & Organoid Epigenet, I-20141 Milan, Italy.;Univ Milan, Dept Oncol & Hematooncol, I-20122 Milan, Italy.
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- Troglio, F. (författare)
- High Definition Disease Modelling Lab, Stem Cell and Organoid Epigenetics, IEO, European Institute of Oncology, IRCCS, Milan, Italy,European Inst Oncol, High Definit Dis Modelling Lab, IRCCS, IEO,Stem Cell & Organoid Epigenet, I-20141 Milan, Italy.
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- Zanella, M. (författare)
- High Definition Disease Modelling Lab, Stem Cell and Organoid Epigenetics, IEO, European Institute of Oncology, IRCCS, Milan, Italy,European Institute of Oncology, ITA;Evotec SE, DEU,European Inst Oncol, High Definit Dis Modelling Lab, IRCCS, IEO,Stem Cell & Organoid Epigenet, I-20141 Milan, Italy.;Evotec SE, Hamburg, Germany.
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- Bergman, Åke, 1950- (författare)
- Stockholm University,Örebro University,Stockholms universitet,Örebro universitet,Institutionen för naturvetenskap och teknik,Swedish Toxicology Sciences Research Center (SWETOX), Södertälje, Sweden; Department of Environmental Science, Stockholm University, Stockholm, Sweden,SWETOX, Swedish Toxicology Sciences ;Stockholm University;Örebro University,Institutionen för miljövetenskap,Swedish Toxicology Sciences Research Center, Sweden; Örebro University, Sweden,Swedish Toxicol Sci Res Ctr SWETOX, Södertälje, Sweden.;Stockholm Univ, Dept Environm Sci, SE-10691 Stockholm, Sweden.;Örebro Univ, Sch Sci & Technol, SE-70182 Örebro, Sweden.
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- Damdimopoulou, P. (författare)
- Karolinska Institutet,Swedish Toxicology Science Center (Swetox),Karolinska University Hospital,Swedish Toxicol Sci Res Ctr SWETOX, Södertälje, Sweden.;Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Obstet & Gynecol, S-14186 Stockholm, Sweden.;Karolinska Universip Hosp, S-14186 Stockholm, Sweden.
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- Jönsson, Maria, 1961- (författare)
- Uppsala universitet,Uppsala University,Miljötoxikologi
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- Kiess, W. (författare)
- Hospital for Children and Adolescents, Department of Women and Child Health, University Hospital, University of Leipzig, Leipzig, Germany,University of Leipzig, DEU,Univ Leipzig, Univ Hosp, Hosp Children & Adolescents, Dept Women & Child Hlth, D-04103 Leipzig, Germany.
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- Kitraki, E. (författare)
- Lab of Basic Sciences, Faculty of Dentistry, National and Kapodistrian University of Athens, Athens, Greece,University of Athens,GRC,Natl & Kapodistrian Univ Athens, Fac Dent, Lab Basic Sci, Athens 15272, Greece.
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- Kiviranta, H. (författare)
- Department of Health Security, Finnish Institute for Health and Welfare (THL), Kuopio, Finland,Finnish Inst Hlth & Welf THL, Dept Hlth Secur, Kuopio 70210, Finland.
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Nånberg, E. (författare)
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- Öberg, M. (författare)
- Karolinska Institute,Karolinska Institutet,Swedish Toxicol Sci Res Ctr SWETOX, Södertälje, Sweden.;Karolinska Inst, Inst Environm Med, SE-17177 Stockholm, Sweden.
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- Rantakokko, P. (författare)
- Department of Health Security, Finnish Institute for Health and Welfare (THL), Kuopio, Finland,Finnish Inst Hlth & Welf THL, Dept Hlth Secur, Kuopio 70210, Finland.
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- Rudén, Christina (författare)
- Stockholm University,Stockholms universitet,Institutionen för miljövetenskap,Stockholm Univ, Dept Environm Sci, SE-10691 Stockholm, Sweden.
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- Söder, O. (författare)
- Karolinska Institute,Karolinska Inst, Dept Womens & Childrens Hlth, Pediat Endocrinol Div, SE-17176 Stockholm, Sweden.;Univ Hosp, SE-17176 Stockholm, Sweden.
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- Bornehag, Carl-Gustaf, 1957- (författare)
- Karlstad University,Karlstads universitet,Institutionen för hälsovetenskaper (from 2013),Icahn School of Medicine at Mount Sinai,Karlstad Univ, Fac Hlth Sci & Technol, Dept Hlth Sci, SE-65188 Karlstad, Sweden.;Icahn Sch Med Mt Sinai, New York, NY 10029 USA.
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- Demeneix, B. (författare)
- UMR 7221, Phyma, CNRS-Muséum National d'Histoire Naturelle, Sorbonne Université, Paris, France,Sorbonne University, FRA,Sorbonne Univ, CNRS Museum Natl dHist Nat, Phyma, UMR 7221, F-75005 Paris, France.
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- Fini, J. B. (författare)
- UMR 7221, Phyma, CNRS-Muséum National d'Histoire Naturelle, Sorbonne Université, Paris, France,Sorbonne University, FRA,Sorbonne Univ, CNRS Museum Natl dHist Nat, Phyma, UMR 7221, F-75005 Paris, France.
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- Gennings, C. (författare)
- Icahn School of Medicine at Mount Sinai, USA,Icahn Sch Med Mt Sinai, New York, NY 10029 USA.
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- Rüegg, Joëlle (författare)
- Uppsala universitet,Uppsala University,Miljötoxikologi,Swedish Toxicol Sci Res Ctr SWETOX, Södertälje, Sweden
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- Sturve, J. (författare)
- University of Gothenburg,Univ Gothenburg, Dept Biol & Environm Sci, S-41463 Gothenburg, Sweden.
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- Testa, G. (författare)
- High Definition Disease Modelling Lab, Stem Cell and Organoid Epigenetics, IEO, European Institute of Oncology, IRCCS, Milan, Italy; Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy; Human Technopole, V.le Rita Levi-Montalcini, Milan, Italy,European Inst Oncol, High Definit Dis Modelling Lab, IRCCS, IEO,Stem Cell & Organoid Epigenet, I-20141 Milan, Italy.;Univ Milan, Dept Oncol & Hematooncol, I-20122 Milan, Italy.;Human Technopole, Vle Rita Levi Montalcini 1, I-20157 Milan, Italy.
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- Chorev, Nadav Even (författare)
- European Institute of Oncology, ITA.;University of Milan, ITA,European Inst Oncol, High Definit Dis Modelling Lab, IRCCS, IEO,Stem Cell & Organoid Epigenet, I-20141 Milan, Italy.
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visa färre...
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High Definition Disease Modelling Lab, Stem Cell and Organoid Epigenetics, IEO, European Institute of Oncology, IRCCS, Milan, Italy; Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy; Human Technopole, Vle Rita Levi-Montalcini, Milan, Italy European Inst Oncol, High Definit Dis Modelling Lab, IRCCS, IEO,Stem Cell & Organoid Epigenet, I-20141 Milan, Italy.;Univ Milan, Dept Oncol & Hematooncol, I-20122 Milan, Italy.;Human Technopole, Vle Rita Levi Montalcini 1, I-20157 Milan, Italy. (creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2022
- 2022
- Engelska.
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 375:6582
- Relaterad länk:
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https://doi.org/10.1...
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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http://kipublication...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Convergent evidence associates exposure to endocrine disrupting chemicals (EDCs) with major human diseases, even at regulation-compliant concentrations. This might be because humans are exposed to EDC mixtures, whereas chemical regulation is based on a risk assessment of individual compounds. Here, we developed a mixture-centered risk assessment strategy that integrates epidemiological and experimental evidence. We identified that exposure to an EDC mixture in early pregnancy is associated with language delay in offspring. At human-relevant concentrations, this mixture disrupted hormone-regulated and disease-relevant regulatory networks in human brain organoids and in the model organisms Xenopus leavis and Danio rerio, as well as behavioral responses. Reinterrogating epidemiological data, we found that up to 54% of the children had prenatal exposures above experimentally derived levels of concern, reaching, for the upper decile compared with the lowest decile of exposure, a 3.3 times higher risk of language delay. © 2022 American Association for the Advancement of Science. All rights reserved.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
- NATURVETENSKAP -- Geovetenskap och miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- endocrine disruptor
- perfluoro compound
- phenol
- phthalic acid
- thyroid hormone
- transcription factor
- brain
- child health
- cohort analysis
- epidemiology
- language
- pollution exposure
- risk assessment
- animal experiment
- animal tissue
- Article
- autism
- brain development
- cerebral organoid
- controlled study
- embryo
- gene expression
- haploinsufficiency
- health hazard
- hormonal regulation
- human
- human cell
- language delay
- neural stem cell
- nonhuman
- prenatal exposure
- Xenopus laevis
- zebra fish
- Public Health Science
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Caporale, N.
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Leemans, M.
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Birgersson, Lina ...
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Germain, P. L.
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Cheroni, C.
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Borbély, G.
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Engdahl, Elin
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Lindh, Christian
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Bressan, R. B.
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Cavallo, F.
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Nånberg, Eewa, 1 ...
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D’Agostino, G. A ...
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Pollard, S. M.
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Rigoli, M. T.
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Tenderini, E.
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Tobon, A. L.
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Trattaro, S.
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Troglio, F.
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Zanella, M.
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Bergman, Åke, 19 ...
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Damdimopoulou, P ...
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Jönsson, Maria, ...
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Kiess, W.
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Kitraki, E.
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Kiviranta, H.
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Nånberg, E.
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Öberg, M.
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Rantakokko, P.
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Rudén, Christina
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Söder, O.
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Bornehag, Carl-G ...
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Demeneix, B.
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Fini, J. B.
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Gennings, C.
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Rüegg, Joëlle
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Sturve, J.
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Testa, G.
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Chorev, Nadav Ev ...
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