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Odor identification...
Odor identification impairment in carriers of ApoE-ε4 is independent of clinical dementia
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- Olofsson, Jonas K, 1965- (författare)
- Stockholms universitet,Umeå universitet,Institutionen för psykologi,Department of Psychology, Stockholm University, Stockholm, Sweden, and Stockholm Brain Institute, Stockholm, Sweden,Perception och psykofysik
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- Nordin, Steven, 1960- (författare)
- Umeå universitet,Institutionen för psykologi,Department of Psychology, San Diego State University, San Diego, USA
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- Wiens, Stefan (författare)
- Stockholms universitet,Perception och psykofysik,Department of Psychology, Stockholm University, Stockholm, Sweden,Stockholm Brain Institute, Stockholm, Sweden
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- Hedner, Margareta (författare)
- Stockholms universitet,Perception och psykofysik,Department of Psychology, Stockholm University, Stockholm, Sweden,Stockholm Brain Institute, Stockholm, Sweden
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- Nilsson, Lars-Göran (författare)
- Stockholms universitet,Kognitiv psykologi,Department of Psychology, Stockholm University, Stockholm, Sweden,Stockholm Brain Institute, Stockholm, Sweden
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- Larsson, Maria (författare)
- Stockholms universitet,Perception och psykofysik,Department of Psychology, Stockholm University, Stockholm, Sweden,Stockholm Brain Institute, Stockholm, Sweden
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(creator_code:org_t)
- Elsevier, 2010
- 2010
- Engelska.
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Ingår i: Neurobiology of Aging. - : Elsevier. - 0197-4580 .- 1558-1497. ; 31:4, s. 567-577
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The ApoE gene is expressed in olfactory brain structures and is believed to play a role in neuronal regenerative processes as well as in development of Alzheimer's disease (AD), the most common form of dementia. The ε4 allele has been reported to be associated with compromised odor identification ability in the elderly, and this deficit has been interpreted as a sign of pre-diagnostic AD. However, because it has not been demonstrated that the relationship between the ε4 allele and odor identification is mediated by dementia, it is possible that the ε4 allele may have an effect on odor identification over and above any effects of dementia. The present study investigated effects of ApoE-status on odor identification in a large, population-based sample (n = 1236) of adults (45–80 years), who were assessed for dementia at time of testing and 5 years later. The results showed that the ε4 allele was associated with an odor identification deficit among elderly participants (75–80). Critically, this effect remained after current and pre-diagnostic dementia, vocabulary, global cognitive status and health variables were partialled out. The present results suggest that the ApoE gene plays a role in olfactory functioning that is independent of dementia conversion within 5 years.
Ämnesord
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Nyckelord
- ApoE
- odor identification
- olfaction
- aging
- Alzheimer's disease
- Psychology
- Psykologi
- Psychology
- psykologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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