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Polymorphisms in me...
Polymorphisms in metabolic genes related to tobacco smoke and the risk of gastric cancer in the European prospective investigation into cancer and nutrition
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Agudo, Antonio (author)
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Sala, Nuria (author)
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Pera, Guillem (author)
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show more...
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Capella, Gabriel (author)
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Berenguer, Antonio (author)
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Garcia, Nadia (author)
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Palli, Domenico (author)
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Boeing, Heiner (author)
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Del Giudice, Giuseppe (author)
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Saieva, Calogero (author)
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Carneiro, Fatima (author)
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Berrino, Franco (author)
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Sacerdote, Carlotta (author)
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Tumino, Rosario (author)
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Panico, Salvatore (author)
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- Berglund, Göran (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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- Simán, Henrik (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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Stenling, Roger (author)
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Hallmans, Goran (author)
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Martinez, Carmen (author)
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Bilbao, Roberto (author)
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Barricarte, Aurelio (author)
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Navarro, Carmen (author)
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Quiros, Jose R. (author)
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Allen, Naomi (author)
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Key, Tim (author)
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Bingham, Sheila (author)
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Khaw, Kay-Tee (author)
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Linseisen, Jakob (author)
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Nagel, Gabriele (author)
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Overvad, Kim (author)
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Tjonneland, Anne (author)
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Olsen, Anja (author)
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Bueno-de-Mesquita, H. Bas (author)
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Boshuizen, Hendriek C. (author)
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Peeters, Petra H. (author)
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Numans, Mattijs E. (author)
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Clavel-Chapelon, Francoise (author)
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Boutron-Ruault, Marie-Christine (author)
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Trichopoulou, Antonia (author)
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Lund, Eiliv (author)
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Offerhaus, Johan (author)
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Jenab, Mazda (author)
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Ferrari, Pietro (author)
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Norat, Teresa (author)
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Riboli, Elio (author)
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Gonzalez, Carlos A. (author)
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(creator_code:org_t)
- 2006
- 2006
- English.
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In: Cancer Epidemiology Biomarkers & Prevention. - 1538-7755. ; 15:12, s. 2427-2434
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- Metabolizing enzymes, which often display genetic polymorphisms, are involved in the activation of compounds present in tobacco smoke that may be relevant to gastric carcinogenesis. We report the results of a study looking at the association between risk of gastric adenocarcinoma and polymorphisms in genes CYP1A1, CYP1A2, EPHX1, and GSTT1. A nested case-control study was carried out within the European Prospective Investigation into Cancer and Nutrition, developed in 10 European countries. The study includes 243 newly diagnosed cases of histologically confirmed gastric adenocarcinoma and 946 controls matched by center, age, sex, and date of blood collection. Genotypes were determined in nuclear DNA from WBCs. We found an increased risk of gastric cancer for homozygotes for C (histidine) variant in Y113H of EPHX1 (odds ratio, 1.91; 95% confidence interval, 1.19-3.07) compared with subjects with TC/TT. There was also a significant increased risk for smokers carrying at least one variant allele A in Ex7+129C > A (m4) of CYP1A1 and never smokers with null GSTT1 and allele A in the locus -3859G > A of CYP1A2. Most of these genes are involved in the activation and detoxification of polycyclic aromatic hydrocarbons, suggesting a potential role of these compounds in gastric carcinogenesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Agudo, Antonio
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Sala, Nuria
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Pera, Guillem
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Capella, Gabriel
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Berenguer, Anton ...
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Garcia, Nadia
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show more...
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Palli, Domenico
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Boeing, Heiner
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Del Giudice, Giu ...
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Saieva, Calogero
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Carneiro, Fatima
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Berrino, Franco
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Sacerdote, Carlo ...
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Tumino, Rosario
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Panico, Salvator ...
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Berglund, Göran
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Simán, Henrik
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Stenling, Roger
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Hallmans, Goran
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Martinez, Carmen
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Bilbao, Roberto
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Barricarte, Aure ...
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Navarro, Carmen
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Quiros, Jose R.
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Allen, Naomi
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Key, Tim
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Bingham, Sheila
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Khaw, Kay-Tee
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Linseisen, Jakob
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Nagel, Gabriele
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Overvad, Kim
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Tjonneland, Anne
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Olsen, Anja
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Bueno-de-Mesquit ...
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Boshuizen, Hendr ...
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Peeters, Petra H ...
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Numans, Mattijs ...
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Clavel-Chapelon, ...
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Boutron-Ruault, ...
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Trichopoulou, An ...
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Lund, Eiliv
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Offerhaus, Johan
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Jenab, Mazda
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Ferrari, Pietro
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Norat, Teresa
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Riboli, Elio
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Gonzalez, Carlos ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Epidemiol ...
- By the university
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Lund University