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Association of etio...
Association of etiological factors across the extreme end and continuous variation in disordered eating in female Swedish twins
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- Dinkler, Lisa (författare)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Gillbergcentrum,Gillberg Neuropsychiatry Centre
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- Taylor, Mark J. (författare)
- Karolinska Institutet,Karolinska Institute
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- Råstam, Maria (författare)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Lund University,Lunds universitet,Barn- och ungdomspsykiatri,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Utvecklingsrelaterade störningar, affektiv sjukdom och ångestsyndrom i barn- och ungdomspsykiatri,Forskargrupper vid Lunds universitet,Child and Adolescent Psychiatry,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Disorders in clinical child and adolescent psychiatry,Lund University Research Groups,Sahlgrenska Academy,Gillbergcentrum,Gillberg Neuropsychiatry Centre
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- Hadjikhani, Nouchine, 1966 (författare)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Harvard Medical School,Gillbergcentrum,Gillberg Neuropsychiatry Centre
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- Bulik, Cynthia M. (författare)
- Karolinska Institutet,Karolinska Institute,University of North Carolina
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- Lichtenstein, Paul (författare)
- Karolinska Institutet,Karolinska Institute
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- Gillberg, Christopher, 1950 (författare)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Gillbergcentrum,Gillberg Neuropsychiatry Centre
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- Lundström, Sebastian (författare)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska Academy,Gillbergcentrum,Centrum för etik, juridik och mental hälsa,Gillberg Neuropsychiatry Centre,Centre for Ethics, Law, and Mental Health
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(creator_code:org_t)
- 2021
- 2021
- Engelska 11 s.
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Ingår i: Psychological Medicine. - 0033-2917 .- 1469-8978. ; 51:5, s. 750-760
- Relaterad länk:
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http://dx.doi.org/10... (free)
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Abstract
Ämnesord
Stäng
- BackgroundAccumulating evidence suggests that many psychiatric disorders etiologically represent the extreme end of dimensionally distributed features rather than distinct entities. The extent to which this applies to eating disorders (EDs) is unknown.MethodsWe investigated if there is similar etiology in (a) the continuous distribution of the Eating Disorder Inventory-2 (EDI-2), (b) the extremes of EDI-2 score, and (c) registered ED diagnoses, in 1481 female twin pairs at age 18 years (born 1992-1999). EDI-2 scores were self-reported at age 18. ED diagnoses were identified through the Swedish National Patient Register, parent-reported treatment and/or self-reported purging behavior of a frequency and duration consistent with DSM-IV criteria. We differentiated between anorexia nervosa (AN) and other EDs.ResultsThe heritability of the EDI-2 score was 0.65 (95% CI 0.61-0.68). The group heritabilities in DeFries-Fulker extremes analyses were consistent over different percentile-based extreme groups [0.59 (95% CI 0.37-0.81) to 0.65 (95% CI 0.55-0.75)]. Similarly, the heritabilities in liability threshold models were consistent over different levels of severity. In joint categorical-continuous models, the twin-based genetic correlation was 0.52 (95% CI 0.39-0.65) between EDI-2 score and diagnoses of other EDs, and 0.26 (95% CI 0.08-0.42) between EDI-2 score and diagnoses of AN. The non-shared environmental correlations were 0.52 (95% CI 0.32-0.70) and 0.60 (95% CI 0.38-0.79), respectively.ConclusionsOur findings suggest that some EDs can partly be conceptualized as the extreme manifestation of continuously distributed ED features. AN, however, might be more distinctly genetically demarcated from ED features in the general population than other EDs.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Nyckelord
- Adolescence
- anorexia nervosa
- eating disorders
- quantitative genetics
- twin study
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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