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A comprehensive ana...
A comprehensive analysis of common IGF1, IGFBP1 and IGFBP3 genetic variation with prospective IGF-I and IGFBP-3 blood levels and prostate cancer risk among
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Schumacher, Fredrick R. (author)
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Cheng, Iona (author)
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Freedman, Matthew L. (author)
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show more...
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Mucci, Lorelei (author)
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Allen, Naomi E. (author)
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Pollak, Michael N. (author)
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Hayes, Richard B. (author)
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Stram, Daniel O. (author)
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Canzian, Frederico (author)
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Henderson, Brian E. (author)
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Hunter, David J. (author)
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Virtamo, Jarmo (author)
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- Manjer, Jonas (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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Gaziano, J. Michael (author)
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Kolonel, Laurence N. (author)
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Tjonneland, Anne (author)
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Albanes, Demetrius (author)
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Calle, Eugenia E. (author)
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Giovannucci, Edward (author)
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Crawford, E. David (author)
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Haiman, Christopher A. (author)
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Kraft, Peter (author)
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Willett, Walter C. (author)
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Thun, Michael J. (author)
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Marchand, Loic Le (author)
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Kaaks, Rudolf (author)
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Feigelson, Heather Spencer (author)
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Bueno-de-Mesquita, H. Bas (author)
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Palli, Domenico (author)
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Riboli, Elio (author)
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Lund, Eliv (author)
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Amiano, Pilar (author)
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Andriole, Gerald (author)
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Dunning, Alison M. (author)
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Trichopoulos, Dimitrios (author)
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Stampfer, Meir J. (author)
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Key, Timothy J. (author)
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Ma, Jing (author)
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(creator_code:org_t)
- 2010-05-19
- 2010
- English.
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In: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 19:15, s. 3089-3101
- Related links:
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http://dx.doi.org/10...
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https://academic.oup...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- The insulin-like growth factor (IGF) pathway has been implicated in prostate development and carcinogenesis. We conducted a comprehensive analysis, utilizing a resequencing and tagging single-nucleotide polymorphism (SNP) approach, between common genetic variation in the IGF1, IGF binding protein (BP) 1, and IGFBP3 genes with IGF-I and IGFBP-3 blood levels, and prostate cancer (PCa) risk, among Caucasians in the NCI Breast and Prostate Cancer Cohort Consortium. We genotyped 14 IGF1 SNPs and 16 IGFBP1/IGFBP3 SNPs to capture common [minor allele frequency (MAF) >= 5%] variation among Caucasians. For each SNP, we assessed the geometric mean difference in IGF blood levels (N = 5684) across genotypes and the association with PCa risk (6012 PCa cases/6641 controls). We present two-sided statistical tests and correct for multiple comparisons. A non-synonymous IGFBP3 SNP in exon 1, rs2854746 (Gly32Ala), was associated with IGFBP-3 blood levels (P-adj = 8.8 x 10(-43)) after adjusting for the previously established IGFBP3 promoter polymorphism A-202C (rs2854744); IGFBP-3 blood levels were 6.3% higher for each minor allele. For IGF1 SNP rs4764695, the risk estimates among heterozygotes was 1.01 (99% CI: 0.90-1.14) and 1.20 (99% CI: 1.06-1.37) for variant homozygotes with overall PCa risk. The corrected allelic P-value was 8.7 x 10(-3). IGF-I levels were significantly associated with PCa risk (P-trend = 0.02) with a 21% increase of PCa risk when compared with the highest quartile to the lowest quartile. We have identified SNPs significantly associated with IGFBP-3 blood levels, but none of these alter PCa risk; however, a novel IGF1 SNP, not associated with IGF-I blood levels, shows preliminary evidence for association with PCa risk among Caucasians.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- By the author/editor
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Schumacher, Fred ...
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Cheng, Iona
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Freedman, Matthe ...
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Mucci, Lorelei
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Allen, Naomi E.
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Pollak, Michael ...
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show more...
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Hayes, Richard B ...
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Stram, Daniel O.
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Canzian, Frederi ...
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Henderson, Brian ...
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Hunter, David J.
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Virtamo, Jarmo
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Manjer, Jonas
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Gaziano, J. Mich ...
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Kolonel, Laurenc ...
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Tjonneland, Anne
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Albanes, Demetri ...
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Calle, Eugenia E ...
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Giovannucci, Edw ...
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Crawford, E. Dav ...
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Haiman, Christop ...
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Kraft, Peter
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Willett, Walter ...
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Thun, Michael J.
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Marchand, Loic L ...
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Kaaks, Rudolf
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Feigelson, Heath ...
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Bueno-de-Mesquit ...
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Palli, Domenico
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Riboli, Elio
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Lund, Eliv
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Amiano, Pilar
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Andriole, Gerald
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Dunning, Alison ...
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Trichopoulos, Di ...
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Stampfer, Meir J ...
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Key, Timothy J.
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Ma, Jing
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Human Molecular ...
- By the university
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Lund University