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Collating data from major European population studies - The CADSET (Chronic airway disease early stratification) clinical research collaboration

Allinson, James (author)
Royal Brompton Hospital & National Heart and Lung Institute, Imperial College London, London, United Kingdom
Afzal, Shoaib (author)
Department of Clinical Biochemistry and the Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark
Colak, Yunus (author)
Department of Clinical Biochemistry and the Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark
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Backman, Helena (author)
Luleå tekniska universitet,Umeå universitet,Avdelningen för hållbar hälsa,Luleå University of Technology, Sweden,Omvårdnad och medicinsk teknik,Department of Public Health and Clinical Medicine, Section of sustainable health/the OLIN unit, Umeå University
Van den Berghe, Maarten (author)
Dept of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Boezen, Marike (author)
Dept of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Breyer, Marie (author)
Ludwig Boltzmann Institute for COPD and Respiratory Epidemiology, Vienna, Austria
Breyer-Kohansal, Robab (author)
Ludwig Boltzmann Institute for COPD and Respiratory Epidemiology, Vienna, Austria
Burghuber, Otto C. (author)
Ludwig Boltzmann Institute for COPD and Respiratory Epidemiology, Vienna, Austria
Faner, Rosa (author)
Centro de Investigación Biomedica en Red Enfermedades Respiratorias, IDIBAPS-Hospital Clinic de Barcelona, Barcelona, Spain
Hartl, Sylvia (author)
Ludwig Boltzmann Institute for COPD and Respiratory Epidemiology, Vienna, Austria
Jarvis, Deborah (author)
Imperial College London, London, United Kingdom
Lahouse, Lies (author)
Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands
Langhammer, Arnulf (author)
HUNT Research Centre, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU, Levanger, Norway
Lundback, Bo (author)
Krefting Research Centre, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
Nwaru, Bright (author)
Krefting Research Centre, Institute of Medicine, Gothenburg, Sweden
Rönmark, Eva (author)
Umeå universitet,Avdelningen för hållbar hälsa,Department of Public Health and Clinical Medicine, Section of sustainable health/the OLIN unit, Umeå University, Umeå, Sweden
Vikjord, Sigrid (author)
HUNT Research Centre, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU, Levanger, Norway
Vonk, Judith (author)
Dept of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Vijnant, Sara (author)
Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
Szabo, Viktoria (author)
Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
Agusti, Alvar (author)
Respiratory Institute, Hospital Clinic, IDIBAPS, CIBERES, Univ, Barcelona, Spain
Donaldson, Gavin (author)
National Heart and Lung Institute, Imperial College London, London, United Kingdom
Wedzicha, Jadwiga (author)
National Heart and Lung Institute, Imperial College London, London, United Kingdom
Vestbo, Jorgen (author)
Manchester University NHS Foundation Trust, Manchester, Manchester Academic Health Science Centre, and Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, United Kingdom
Vanfleteren, Lowie (author)
COPD center, Institute of Medicine, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden
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 (creator_code:org_t)
2020-10-28
2020
English.
In: European Respiratory Journal. - : European Respiratory Society (ERS). - 0903-1936 .- 1399-3003. ; 56:suppl 64
Related links:
https://urn.kb.se/re...
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https://doi.org/10.1...
https://urn.kb.se/re...
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  • Journal article (other academic/artistic)
Abstract Subject headings
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  • Background: European population cohorts continue to expand our understanding of chronic airways disease and inter-study collaboration may help address the inevitable limitations of study size, duration, era and geography. Towards this aim, CADSET has collated data from ten major general population European cohorts: Asklepios; Copenhagen City Heart Study; Copenhagen General Population Study; ECRHS; HUNT; LEAD; Lifelines, OLIN, Rotterdam Study and WSAS. We included males and females aged 20 to 95 years with baseline demographic and spirometry data.Results: Data from 262,829 individuals (44% male) from multiple European countries provided good coverage across all adult ages (Fig.1A). Recruitment occurred in every year from 1976 through 2020. 23% were current-smokers and 42% were never-smokers, a pattern varying with advancing age (Fig.1B). The prevalence of airflow limitation varied according to whether lower limit of normal (LLN) or <0.70 thresholds were applied, increasing with age if the latter was used (Fig.1C).Interpretation: These results fit with previous reports, however the size, geographical reach and span of recruitment provided by this collaboration provides a unique opportunity to explore chronic airways disease development. Together, we are now pursuing research questions previously beyond the scope of individual cohort studies.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Omvårdnad (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nursing (hsv//eng)

Keyword

COPD
Smoking
Spirometry
Nursing

Publication and Content Type

vet (subject category)
art (subject category)

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