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A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci

Rothman, Nathaniel (author)
Garcia-Closas, Montserrat (author)
Chatterjee, Nilanjan (author)
show more...
Malats, Nuria (author)
Wu, Xifeng (author)
Figueroa, Jonine D (author)
Real, Francisco X (author)
Van Den Berg, David (author)
Matullo, Giuseppe (author)
Baris, Dalsu (author)
Thun, Michael (author)
Kiemeney, Lambertus A (author)
Vineis, Paolo (author)
De Vivo, Immaculata (author)
Albanes, Demetrius (author)
Purdue, Mark P (author)
Rafnar, Thorunn (author)
Hildebrandt, Michelle A T (author)
Kiltie, Anne E (author)
Cussenot, Olivier (author)
Golka, Klaus (author)
Kumar, Rajiv (author)
Taylor, Jack A (author)
Mayordomo, Jose I (author)
Jacobs, Kevin B (author)
Kogevinas, Manolis (author)
Hutchinson, Amy (author)
Wang, Zhaoming (author)
Fu, Yi-Ping (author)
Prokunina-Olsson, Ludmila (author)
Burdett, Laurie (author)
Yeager, Meredith (author)
Wheeler, William (author)
Tardón, Adonina (author)
Serra, Consol (author)
Carrato, Alfredo (author)
García-Closas, Reina (author)
Lloreta, Josep (author)
Johnson, Alison (author)
Schwenn, Molly (author)
Karagas, Margaret R (author)
Schned, Alan (author)
Andriole, Gerald (author)
Grubb, Robert (author)
Black, Amanda (author)
Jacobs, Eric J (author)
Diver, W Ryan (author)
Gapstur, Susan M (author)
Weinstein, Stephanie J (author)
Virtamo, Jarmo (author)
Cortessis, Victoria K (author)
Gago-Dominguez, Manuela (author)
Pike, Malcolm C (author)
Stern, Mariana C (author)
Yuan, Jian-Min (author)
Hunter, David J (author)
McGrath, Monica (author)
Dinney, Colin P (author)
Czerniak, Bogdan (author)
Chen, Meng (author)
Yang, Hushan (author)
Vermeulen, Sita H (author)
Aben, Katja K (author)
Witjes, J Alfred (author)
Makkinje, Remco R (author)
Sulem, Patrick (author)
Besenbacher, Soren (author)
Stefansson, Kari (author)
Riboli, Elio (author)
Brennan, Paul (author)
Panico, Salvatore (author)
Navarro, Carmen (author)
Allen, Naomi E (author)
Bueno-de-Mesquita, H Bas (author)
Trichopoulos, Dimitrios (author)
Caporaso, Neil (author)
Landi, Maria Teresa (author)
Canzian, Federico (author)
Ljungberg, Börje (author)
Umeå universitet,Urologi och andrologi
Tjonneland, Anne (author)
Clavel-Chapelon, Francoise (author)
Bishop, David T (author)
Teo, Mark T W (author)
Knowles, Margaret A (author)
Guarrera, Simonetta (author)
Polidoro, Silvia (author)
Ricceri, Fulvio (author)
Sacerdote, Carlotta (author)
Allione, Alessandra (author)
Cancel-Tassin, Geraldine (author)
Selinski, Silvia (author)
Hengstler, Jan G (author)
Dietrich, Holger (author)
Fletcher, Tony (author)
Rudnai, Peter (author)
Gurzau, Eugen (author)
Koppova, Kvetoslava (author)
Bolick, Sophia C E (author)
Godfrey, Ashley (author)
Xu, Zongli (author)
Sanz-Velez, José I (author)
D García-Prats, María (author)
Sanchez, Manuel (author)
Valdivia, Gabriel (author)
Porru, Stefano (author)
Benhamou, Simone (author)
Hoover, Robert N (author)
Fraumeni, Joseph F (author)
Silverman, Debra T (author)
Chanock, Stephen J (author)
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 (creator_code:org_t)
2010-10-24
2010
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 978-984
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

Keyword

confers susceptibility; udp-glucuronosyltransferases; recombination hotspots; telomerase mutations; pulmonary-fibrosis; sequence variant; common variants; chromosome 8q24; down-regulation; cell-carcinoma

Publication and Content Type

ref (subject category)
art (subject category)

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By the author/editor
Rothman, Nathani ...
Garcia-Closas, M ...
Chatterjee, Nila ...
Malats, Nuria
Wu, Xifeng
Figueroa, Jonine ...
show more...
Real, Francisco ...
Van Den Berg, Da ...
Matullo, Giusepp ...
Baris, Dalsu
Thun, Michael
Kiemeney, Lamber ...
Vineis, Paolo
De Vivo, Immacul ...
Albanes, Demetri ...
Purdue, Mark P
Rafnar, Thorunn
Hildebrandt, Mic ...
Kiltie, Anne E
Cussenot, Olivie ...
Golka, Klaus
Kumar, Rajiv
Taylor, Jack A
Mayordomo, Jose ...
Jacobs, Kevin B
Kogevinas, Manol ...
Hutchinson, Amy
Wang, Zhaoming
Fu, Yi-Ping
Prokunina-Olsson ...
Burdett, Laurie
Yeager, Meredith
Wheeler, William
Tardón, Adonina
Serra, Consol
Carrato, Alfredo
García-Closas, R ...
Lloreta, Josep
Johnson, Alison
Schwenn, Molly
Karagas, Margare ...
Schned, Alan
Andriole, Gerald
Grubb, Robert
Black, Amanda
Jacobs, Eric J
Diver, W Ryan
Gapstur, Susan M
Weinstein, Steph ...
Virtamo, Jarmo
Cortessis, Victo ...
Gago-Dominguez, ...
Pike, Malcolm C
Stern, Mariana C
Yuan, Jian-Min
Hunter, David J
McGrath, Monica
Dinney, Colin P
Czerniak, Bogdan
Chen, Meng
Yang, Hushan
Vermeulen, Sita ...
Aben, Katja K
Witjes, J Alfred
Makkinje, Remco ...
Sulem, Patrick
Besenbacher, Sor ...
Stefansson, Kari
Riboli, Elio
Brennan, Paul
Panico, Salvator ...
Navarro, Carmen
Allen, Naomi E
Bueno-de-Mesquit ...
Trichopoulos, Di ...
Caporaso, Neil
Landi, Maria Ter ...
Canzian, Federic ...
Ljungberg, Börje
Tjonneland, Anne
Clavel-Chapelon, ...
Bishop, David T
Teo, Mark T W
Knowles, Margare ...
Guarrera, Simone ...
Polidoro, Silvia
Ricceri, Fulvio
Sacerdote, Carlo ...
Allione, Alessan ...
Cancel-Tassin, G ...
Selinski, Silvia
Hengstler, Jan G
Dietrich, Holger
Fletcher, Tony
Rudnai, Peter
Gurzau, Eugen
Koppova, Kvetosl ...
Bolick, Sophia C ...
Godfrey, Ashley
Xu, Zongli
Sanz-Velez, José ...
D García-Prats, ...
Sanchez, Manuel
Valdivia, Gabrie ...
Porru, Stefano
Benhamou, Simone
Hoover, Robert N
Fraumeni, Joseph ...
Silverman, Debra ...
Chanock, Stephen ...
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Medical Genetics
Articles in the publication
Nature Genetics
By the university
Umeå University

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