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Serotonin synthesis...
Serotonin synthesis rate and the tryptophan hydroxylase-2: G-703T polymorphism in social anxiety disorder
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- Furmark, Tomas (author)
- Uppsala universitet,Institutionen för psykologi,Uppsala University, Sweden
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- Marteinsdottir, Ina (author)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken
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- Frick, Andreas (author)
- Uppsala universitet,Institutionen för psykologi,Uppsala University, Sweden
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- Heurling, Kerstin (author)
- Uppsala universitet,Radiologi,Uppsala University, Sweden
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- Tillfors, Maria, 1963- (author)
- Örebro universitet,Institutionen för juridik, psykologi och socialt arbete,Univ Orebro, Ctr Hlth & Med Psychol, Orebro, Sweden,University of Örebro, Sweden
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- Appel, Lieuwe (author)
- Uppsala universitet,Radiologi,Uppsala University, Sweden
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- Antoni, Gunnar (author)
- Uppsala universitet,Avdelningen för Molekylär Avbildning,Uppsala University, Sweden
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- Hartvig, P. (author)
- Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Dept Drug Design & Pharmacol, Copenhagen, Denmark
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- Fischer, Håkan (author)
- Stockholms universitet,Biologisk psykologi
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- Långström, Bengt (author)
- Uppsala universitet,Organisk kemi,Southern Denmark Univ, Odense Univ Hosp, Odense, Denmark,Uppsala University, Sweden; Southern Denmark University, Denmark
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- Eriksson, E. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology,Department of Pharmacology, Göteborg University, Göteborg, Sweden,Gothenburg Univ, Dept Pharmacol, Gothenburg, Sweden,Gothenburg University, Sweden
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- Fredrikson, Mats (author)
- Karolinska Institutet,Uppsala universitet,Institutionen för psykologi,Karolinska Inst, Dept Neurosci, Stockholm, Sweden,Uppsala University, Sweden; Karolinska Institute, Sweden,Uppsala universitet; KI
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(creator_code:org_t)
- 2016-07-10
- 2016
- English.
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In: Journal of Psychopharmacology. - London, United Kingdom : SAGE Publications. - 0269-8811 .- 1461-7285. ; 30:10, s. 1028-1035
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Abstract
Subject headings
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- It is disputed whether anxiety disorders, like social anxiety disorder, are characterized by serotonin over- or underactivity. Here, we evaluated whether our recent finding of elevated neural serotonin synthesis rate in patients with social anxiety disorder could be reproduced in a separate cohort, and whether allelic variation in the tryptophan hydroxylase-2 (TPH2) G-703T polymorphism relates to differences in serotonin synthesis assessed with positron emission tomography. Eighteen social anxiety disorder patients and six healthy controls were scanned during 60 minutes in a resting state using positron emission tomography and 5-hydroxy-L-[ -C-11]tryptophan, [C-11]5-HTP, a substrate of the second enzymatic step in serotonin synthesis. Parametric images were generated, using the reference Patlak method, and analysed using Statistical Parametric Mapping (SPM8). Blood samples for genotyping of the TPH2 G-703T polymorphism were obtained from 16 social anxiety disorder patients (T carriers: n=5, GG carriers: n=11). A significantly elevated [C-11]5-HTP accumulation rate, indicative of enhanced decarboxylase activity and thereby serotonin synthesis capacity, was detected in social anxiety disorder patients compared with controls in the hippocampus and basal ganglia nuclei and, at a more lenient (uncorrected) statistical threshold, in the amygdala and anterior cingulate cortex. In patients, the serotonin synthesis rate in the amygdala and anterior cingulate cortex was significantly elevated in TPH2 T carriers in comparison with GG homozygotes. Our results support that social anxiety disorder entails an overactive presynaptic serotonergic system that, in turn, seems functionally influenced by the TPH2 G-703T polymorphism in emotionally relevant brain regions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Keyword
- Serotonin synthesis
- [C-11]5-HTP
- brain
- anxiety
- gene
- positron emission tomography
- human tryptophan-hydroxylase-2 gene
- predicts amygdala reactivity
- positron-emission-tomography
- human brain
- in-vivo
- transporter
- phobia
- system
- stress
- pet
- Neurosciences & Neurology
- Pharmacology & Pharmacy
- Psychiatry
- Serotonin synthesis
- Psychiatry
- Neurology
- Psychology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Furmark, Tomas
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Marteinsdottir, ...
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Frick, Andreas
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Heurling, Kersti ...
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Tillfors, Maria, ...
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Appel, Lieuwe
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Antoni, Gunnar
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Hartvig, P.
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Fischer, Håkan
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Långström, Bengt
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Eriksson, E.
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Fredrikson, Mats
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmacology and ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- SOCIAL SCIENCES
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SOCIAL SCIENCES
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and Psychology
- Articles in the publication
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Journal of Psych ...
- By the university
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University of Gothenburg
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Örebro University
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Uppsala University
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Linköping University
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Karolinska Institutet
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Stockholm University
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Karlstad University
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