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Correlates of risk ...
Correlates of risk factors for reduced life expectancy in schizophrenia: Is it possible to develop a predictor profile?
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- Moradi, Hawar (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Department of Psychiatry, NU Health Care Hospital, Trollhättan, Sweden & Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Sweden
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- Harvey, P. D. (författare)
- Department of Psychiatry, University of Miami Miller School of Medicine, United States & Research Service, Bruce W. Carter VA Medical Center, Miami, FL, United States
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- Helldin, Lars (författare)
- Karlstads universitet,Institutionen för sociala och psykologiska studier (from 2013),Department of Psychiatry, NU Health Care Hospital, Trollhättan, Sweden
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- Engelska.
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Ingår i: Schizophrenia Research. - : Elsevier BV. - 0920-9964 .- 1573-2509. ; 201:November, s. 388-392
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Abstract
Ämnesord
Stäng
- Patients with schizophrenia have significantly greater mortality rates than the general population, with an estimated reduced lifespan of 10-20 years. We previously reported on a link between impairment in cognition and premature death in a prospective 20-year study. Patients who had died prematurely showed neurocognitive impairment in nine different cognitive tests compared to those who did not. Based on those findings, in this study the surviving patients in the cohort were divided into three different groups based on neurocognitive impairment and compared on symptom severity including remission status, RAND-36, weight and BMI at onset of illness and baseline of the study, and medical/physical symptomatology (i.e., blood pressure, symptom awareness, vertigo and orthostatic symptoms). Differences were most prominent between the cognitively unimpaired and severely cognitively impaired (SCI) groups, with remission, negative symptoms, general symptoms and PANSS total scores differing. For SF-36 (RAND) Physical functioning and Role limitations due to physical health subscales the SCI were worst. The findings indicate that greater impairments in cognitive ability during the illness are associated with several potential indicators of risk for early mortality. Together these factors may be of guidance for establishing an algorithm to detect patients at risk of premature death early in their illness. (C) 2018 Elsevier B.V. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Nyckelord
- Schizophrenia
- Premature death
- Early detection of risk factors
- negative syndrome scale
- mortality
- disorder
- remission
- people
- Psychiatry
- Early detection of risk factors
- Psykologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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